637354-25-7

Basic information

• Product Name: 2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine
• Synonyms: 2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine
• CAS NO: 637354-25-7
• Molecular Formula: C10H9N3O2S
• Molecular Weight: 235.26236
• EINECS: 604-604-1
• Mol File: 637354-25-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine(637354-25-7)
• EPA Substance Registry System: 2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine(637354-25-7)

Safety Data

• Hazardous Substances Data: 637354-25-7(Hazardous Substances Data)

Usage

Uses

Used in Endocrinology:
2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine is used as a diagnostic tool for adrenal insufficiency, aiding in the identification of this condition by disrupting the normal cortisol production process.
Used in Treatment of Adrenal Disorders:
In the medical field, 2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine serves as a treatment option for specific adrenal gland disorders, helping to manage the symptoms and effects of these conditions.
Used in Research and Treatment of Cushing's Syndrome:
2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine is utilized in the research and potential treatment of Cushing's syndrome, a condition marked by an overproduction of cortisol, to help regulate cortisol levels.
Used in Cognitive Function and Memory Enhancement Studies:
Although still under investigation, 2-(Methylsulfonyl)-4-(pyridin-3-yl) pyriMidine has been studied for its potential to enhance cognitive function and memory, indicating possible applications in neurological research and treatment.

Upstream product

• 637354-24-6 2-(methylsulfanyl)-4-(3-pyridyl)pyrimidine 
• 55314-16-4 3-(N,N-dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 
• 55314-16-4 (E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one 

Relevant articles and documents

Synthetic method of N-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidinamine

The invention discloses a synthetic method of N-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidinamine. The synthetic method comprises the following steps: (1) synthesizing 2-(methylthio)-4-(3-pyridyl) pyrimidine; (2) synthesizing 2-(methylsulfonyl)-4-(3-pyridine) pyrimidine; (3) synthesizing N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidinamine and (4) synthesizing the N-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidinamine. Synthesis raw materials used in the method are low in price and easy to obtain, reaction conditions are mild, the product yield and purity are high, and the methodis suitable for industrial production. Therefore, the synthetic method disclosed by the invention has good advantages in the aspects of production cost control, environmental friendliness and productquality improvement.

2,3-dimethyl-6-urea -2H-indazoles and its preparation method and application

The invention discloses a 2, 3-dimethyl-6-urea-2H-indazole compound shown by the following general formula (I), medicinal salt or a solvent compound thereof, wherein Ar is substituted or unsubstituted phenyl or aromatic matrix. The invention also discloses a preparation method and application of the compound. The compound can regulate signal transduction of tyrosine kinase, inhibit bad cellular proliferation, and particularly has obvious curative effect for tumors.

A novel synthesis of imatinib and its intermediates

A convenient method has been developed for the synthesis of imatinib and two of its intermediates. N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidin amine, obtained from 2-(methylsulfonyl)-4-(3-pyridyl)pyrimidine via nucleophilic substitution, was reduced by N2H4H2O/FeCl 3·6H2O/C in 92% yield. The resulting amine was condensed with 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride, which was prepared from 4-(chloromethyl)benzonitrile via substitution and hydrolysis reactions, to provide the final product imatinib in good yield and high purity. Springer-Verlag 2010.

Synthesis and crystal structure of 2-(methylsulfonyl)-4-(pyridin-3-yl)pyrimidine

A new compound with molecular formula as C10H9N3O2S, was derived from 2-(methylthio)-4-(pyridin-3-yl)pyrimidine. The crystal is monoclinic, space group C2/c with unit cell parameters: a = 5.4625 (8) ?, b = 10.8235 (16) ?, c = 17.520 (3) ?, α = 90° β = 97.460 (3)°, γ = 90°, V = 1027.1 (3) ?3, Z = 4, Mr = 235.00, Dc = 1.521 g/cm3, μ = 0.300 mm-1, F(000) = 488, R = 0.0443, wR = 0.1061 for 2413 reflections with I > 2σ(I).