6377-63-5

Basic information

• Product Name: 1-CHLORO-4-(P-TOLYLOXY)BENZENE
• Synonyms: 1-CHLORO-4-(P-TOLYLOXY)BENZENE
• CAS NO: 6377-63-5
• Molecular Formula: C₁₃H₁₁ClO
• Molecular Weight: 218.67884
• Mol File: 6377-63-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 299.466°C at 760 mmHg
• Flash Point: 136.911°C
• Appearance: /
• Density: 1.162g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 1-CHLORO-4-(P-TOLYLOXY)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-4-(P-TOLYLOXY)BENZENE(6377-63-5)
• EPA Substance Registry System: 1-CHLORO-4-(P-TOLYLOXY)BENZENE(6377-63-5)

Safety Data

• Hazardous Substances Data: 6377-63-5(Hazardous Substances Data)

Usage

Type of Compound

Organic chemical compound

Aromaticity

Aromatic

Functional Groups

Chlorine atom, p-tolyl group, benzene ring

Usage

Building block in the synthesis of various organic compounds and pharmaceuticals

Applications

Intermediate in the production of insecticides, dyes, and other industrial chemicals

Reactivity

Potential use as a reagent in organic chemistry reactions

Research and Development

Valuable for research and development in the field of organic synthesis

InChI:InChI=1/C13H11ClO/c1-10-2-6-12(7-3-10)15-13-8-4-11(14)5-9-13/h2-9H,1H3

Upstream product

• 106-38-7 para-bromotoluene 
• 1121-74-0 potassium 4-chlorophenoxide 
• 41295-20-9 4-(4-methylphenoxy)aniline 
• 624-31-7 4-tolyl iodide 
• 106-48-9 4-chloro-phenol 
• 106-44-5 p-cresol 
• 637-87-6 1-Chloro-4-iodobenzene 
• 100-00-5 4-chlorobenzonitrile 
• 1428064-59-8 2,4-dimethoxyphenyl(4-methylphenyl)iodonium tosylate 
• 1428064-54-3 4-chlorophenyl(2,4-dimethoxyphenyl)iodonium tosylate 
• 59696-06-9 bis(4-chlorophenyl)iodonium tosylate 
• 73177-96-5 <(hydroxy)(tosyloxy)iodo>-p-toluene 
• 73178-07-1 -p-chlorobenzene 
• 108-90-7 chlorobenzene 

Downstream Products

• 106-48-9 4-chloro-phenol 
• 21120-67-2 4-(4'-chlorophenoxy)-benzoic acid 
• 74448-92-3 4-(4'-chlorophenoxy)benzonitrile 
• 134312-17-7 2-<(p-chlorophenyl)oxy>-5-methylbenzophenone 
• 134312-24-6 1-<2-<(p-chlorophenyl)oxy>-5-methylphenyl>-1,2-diphenylethene 
• 134312-27-9 3-chloro-7-methyl-10,11-diphenyldibenzoxepin 
• 134333-40-7 1-bromo-2-<2-<(p-chlorophenyl)oxy>-5-methylphenyl>-1,2-diphenylethene 
• 134312-19-9 1-<2-<(p-chlorophenyl)oxy>-5-methylphenyl>-1,2-diphenylethanol 
• 134312-30-4 2-<2-<(p-chlorophenyl)oxy>-5-methylphenyl>-1-methoxy-1,2-diphenylethene 
• 134312-33-7 1-acetoxy-<2-<(p-chlorophenyl)oxy>-5-methylphenyl>-1,2-diphenylethene 
• 21153-22-0 2-chloro-8-methyl-10-phenyl-10H-phenoxaphosphine 10-oxide 
• 21153-29-7 (2-chloro-8-methyl-10-oxo-10H-10λ⁵-phenoxaphosphin-10-yl)-phenyl-amine 
• 21153-21-9 8-chloro-10-oxo-10-phenyl-10H-10λ⁵-phenoxaphosphine-2-carboxylic acid 
• 21071-78-3 8-chloro-10-oxo-10-phenyl-10H-10λ⁵-phenoxaphosphine-2-carboxylic acid (R)-1-phenyl-ethylamide 

Relevant articles and documents

CoII Immobilized on Aminated Magnetic-Based Metal–Organic Framework: An Efficient Heterogeneous Nanostructured Catalyst for the C–O Cross-Coupling Reaction in Solvent-Free Conditions

Abstract: In this paper, we report the synthesis of Fe3O4?AMCA-MIL53(Al)-NH2-CoII NPs based on the metal–organic framework structures as a magnetically separable and environmentally friendly heterogeneous nanocatalyst. The prepared nanostructured catalyst efficiently promotes the C–O cross-coupling reaction in solvent-free conditions without the need for using toxic solvents and/or expensive palladium catalyst. Graphic Abstract: [Figure not available: see fulltext.].

Preparation method of diaryl ether compound

The invention relates to a preparation method of a diaryl ether compound. Particularly, under catalysis of chitosan supported cuprous oxide, an arylation reaction used for phenols is achieved, the corresponding diaryl ether compound is obtained, the technological condition is simple, the yield is good, operability is high, and wide functional group durability is achieved.

Copper-catalyzed Ullmann-type synthesis of diaryl ethers assisted by salicylaldimine ligands

A series of salicylaldimine ligands were designed to promote the copper-catalyzed Ullmann cross-coupling reaction. After a screening process, 2-((2-isopropylphenylimino)methyl)phenol was found to serve as a good supporting ligand for this reaction. Employing this Schiff-base ligand as a new supporting ligand, the copper-catalyzed coupling reactions of aryl bromides and aryl iodides with various phenols successfully proceeded in good yields under mild conditions. Various diaryl ethers were obtained with excellent yields in dioxane in the presence of K3PO4 and a catalytic amount of copper(I) salt.