638211-23-1

Basic information

• Product Name: (S_S,2S)-2-methyl-propane-2-sulfinic acid (2-benzyloxypropylidene)-amide
• Synonyms: (S_S,2S)-2-methyl-propane-2-sulfinic acid (2-benzyloxypropylidene)-amide
• CAS NO: 638211-23-1
• Molecular Weight: 267.392
• Mol File: 638211-23-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S_S,2S)-2-methyl-propane-2-sulfinic acid (2-benzyloxypropylidene)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (S_S,2S)-2-methyl-propane-2-sulfinic acid (2-benzyloxypropylidene)-amide(638211-23-1)
• EPA Substance Registry System: (S_S,2S)-2-methyl-propane-2-sulfinic acid (2-benzyloxypropylidene)-amide(638211-23-1)

Safety Data

• Hazardous Substances Data: 638211-23-1(Hazardous Substances Data)

Upstream product

• 81445-44-5 (S)-2-(benzyloxy)propanal 
• 343338-28-3 (S)-2-methylpropane-2-sulfinamide 
• 53346-05-7 (R)-2-benzyloxypropanal 

Downstream Products

• 1602920-58-0 (3R,4S,S_S)-ethyl 4-(benzyloxy)-3-(tert-butylsulfinamino)-2,2-difluoropentanoate 
• 1602920-59-1 (3S,4S,S_S)-ethyl 4-(benzyloxy)-3-(tert-butylsulfinamino)-2,2-difluoropentanoate 
• 638211-25-3 (S_S,2S)-2-methyl-propane-2-sulfinic acid (2-benzyloxy-1-phenyl-propyl)-amide 
• 638211-26-4 (S_S,2S)-2-methyl-propane-2-sulfinic acid (2-benzyloxy-1-ethyl-propyl)-amide 
• 638211-29-7 (S_S,4S)-4-benzyloxy-3-(2-methyl-propane-2-sulfinylamino)-pentanoic acid methyl ester 

Relevant articles and documents

One-pot microwave-promoted synthesis of nitriles from aldehydes via tert-butanesulfinyl imines

A facile, one-pot method for the synthesis of nitriles from aldehydes via a microwave-promoted, concerted elimination of tert-butanesulfenic acid from tert-butanesulfinyl-protected imines, is described. The mild reaction conditions exhibit broad functional group compatibility and generate products in good isolated yield (69-87%). This method provides a rapid and mild procedure for the synthesis of various functionalized nitriles. Georg Thieme Verlag Stuttgart.

BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS

The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof. The compounds are inhibitors of ERK 1/2 kinases and will be useful in the treatment of ERKl/2-mediated conditions. The compounds are therefore useful in therapy, in particular in the treatment of cancer.

Stereoselective Synthesis of 1,2-Disubstituted β-Amino Alcohols by Nucleophilic Addition to N-tert-Butanesulfinyl α-Alkoxyaldimines

N-tert-Butanesulfinyl α-alkoxyaldimines are readily prepared from protected (S)-lactals without epimerization at the α-stereocenter. Addition of ethyl and phenyl Grignard reagents, as well as the titanium enolate of methyl acetate, to the N-tert-butanesul