6421-88-1

Basic information

• Product Name: 2-(4-aminophenoxy)ethanol
• Synonyms: 2-(4-aminophenoxy)ethanol;4-(2-hydroxyethoxy)aniline;Ai3-23465;Einecs 229-174-8;Ethanol, 2-(4-aminophenoxy)-
• CAS NO: 6421-88-1
• Molecular Formula: C₈H₁₁NO₂
• Molecular Weight: 153.17844
• EINECS: 229-174-8
• Mol File: 6421-88-1.mol
• Article Data: 28

Chemical Properties

• Melting Point: 73-74 °C
• Boiling Point: 327.5°C at 760 mmHg
• Flash Point: 151.9°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 8.14E-05mmHg at 25°C
• Refractive Index: 1.582
• PKA: 14.40±0.10(Predicted)
• CAS DataBase Reference: 2-(4-aminophenoxy)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-aminophenoxy)ethanol(6421-88-1)
• EPA Substance Registry System: 2-(4-aminophenoxy)ethanol(6421-88-1)

Safety Data

• Hazardous Substances Data: 6421-88-1(Hazardous Substances Data)

Usage

General Description

2-(4-aminophenoxy)ethanol, also known as 4-(2-hydroxyethoxy)aniline, is an organic compound with the chemical formula C8H11NO2. It is a colorless to pale yellow liquid that is used in the manufacturing of various products, including dyes, pharmaceuticals, and surfactants. 2-(4-aminophenoxy)ethanol is also utilized as an intermediate in the production of other chemicals and is known for its ability to form stable complexes with metal ions. 2-(4-aminophenoxy)ethanol is considered to be a relatively low toxicity compound and is generally regarded as safe for use in approved applications.

InChI:InChI=1/C8H11NO2/c9-7-1-3-8(4-2-7)11-6-5-10/h1-4,10H,5-6,9H2

Upstream product

• 100-00-5 4-chlorobenzonitrile 
• 350-46-9 4-Fluoronitrobenzene 
• 100-02-7 4-nitro-phenol 
• 103-90-2 4-acetaminophenol 
• 824-78-2 4-nitrophenol sodium salt 
• 64-17-5 ethanol 
• 16365-27-8 2-(4-nitrophenoxy)ethanol 
• 50375-15-0 2-[4-(acetylamino)phenoxy]ethanol 
• 855877-09-7 acetic acid-[4-(2-benzyloxy-ethoxy)-anilide] 
• 28341-54-0 4-(4-nitrophenoxy)butanoic acid 
• 122-99-6 2-Phenoxyethanol 

Downstream Products

• 395-90-4 2-<4-(2-nitro-4-trifluoromethylanilino)phenoxy>ethanol 
• 96740-81-7 1-acetoxy-2-(4-acetylamino-phenoxy)-ethane 
• 58979-45-6 1-hydroxy-4-[4-(2-hydroxy-ethoxy)-anilino]-anthraquinone 

Relevant articles and documents

Copper nanoparticles (CuNPs) catalyzed chemoselective reduction of nitroarenes in aqueous medium

Abstract: A procedure for practical synthesis of CuNPs from CuSO4·5H2O is established, under appropriate reaction conditions, using rice (Oryza sativa) as an economic source of reducing as well as a stabilizing agent. Optical and microscopic techniques are employed for the characterization of the synthesized CuNPs and the sizes of the particles were found to be in the range of 8 ± 2 nm. The nanoparticles are used as a catalyst for chemoselective reduction of aromatic nitro compounds to corresponding amines under ambient conditions and water as a reaction medium. Graphic abstract: CuNPs are synthesized using hydrolysed rice and used as catalyst for chemoselective reduction of nitroarenes to their corresponding amines in water. [Figure not available: see fulltext.]

INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS AND USE OF SAME IN MEDICINE

The present invention relates to a compound represented by formula I, a pharmaceutical composition containing the compound of formula I, a method for inhibiting indoleamine 2,3-dioxygenase, and its use in medicine.

Cu(II)-Mediated N-H and N-Alkyl Aryl Amination and Olefin Aziridination

Cu(II)-mediated direct NH2 and NH alkyl aryl aminations and olefin aziridinations are described. These room-temperature, one-pot, environmentally friendly procedures replace costly Rh2 catalysts and, in some instances, display important differences with comparable Rh2- and Fe-supported reactions.