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64363-77-5

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64363-77-5 Usage

General Description

Methyl 2,3,5-tri-O-benzyl-D-ribofuranoside is a chemical compound that consists of a ribofuranoside sugar molecule with three benzyl groups attached to the hydroxyl groups at the 2, 3, and 5 positions. Methyl 2,3,5-tri-O-benzyl-D-ribofuranoside is often used in organic synthesis and medicinal chemistry for the modification of nucleosides and nucleotides. The benzyl groups provide protection for the hydroxyl groups, allowing for selective manipulation of the sugar moiety without affecting other parts of the molecule. Methyl 2,3,5-tri-O-benzyl-D-ribofuranoside is an important building block in the synthesis of various bioactive compounds and pharmaceuticals.

Check Digit Verification of cas no

The CAS Registry Mumber 64363-77-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,3,6 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 64363-77:
(7*6)+(6*4)+(5*3)+(4*6)+(3*3)+(2*7)+(1*7)=135
135 % 10 = 5
So 64363-77-5 is a valid CAS Registry Number.

64363-77-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (3R,4R,5R)-2-methoxy-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolane

1.2 Other means of identification

Product number -
Other names methyl-2,3,5-tri-O-benzyl-D-riboside

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:64363-77-5 SDS

64363-77-5Relevant articles and documents

Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1

Filippov, Dmitri V.,Knobloch, Gunnar,Ladurner, Andreas G.,Liu, Qiang,Meeuwenoord, Nico J.,Overkleeft, Herman S.,Voorneveld, Jim,van der Marel, Gijsbert A.

, p. 12468 - 12475 (2021)

ADP-ribosylation is a pivotal post-translational modification that mediates various important cellular processes producing negatively charged biopolymer, poly (ADP-ribose), the functions of which need further elucidation. Toward this end, the availability

Synthesis of remdesivir key intermediate 2, 3, 5-tribenzyloxy-D-ribotide-1, 4-lactone

-

, (2020/07/21)

The invention relates to synthesis of a remdesivir key intermediate 2, 3, 5-tribenzyloxy-D-ribotide-1, 4-lactone. The invention discloses a synthesis method of 2, 3, 5-tribenzyloxy-D-ribotide-1, 4-lactone, and belongs to the field of organic synthesis. The method includes: taking D-ribose as an initial raw material, in methanol, using concentrated sulfuric acid as a catalyst, synthesizing a methoxy compound 2, then fully stirring the substances in a saturated sodium hydroxide solution, adding tetrahydrofuran and n-butylammonium hydrogen sulfate, and then adding benzyl bromide to synthesize a compound 3, dissolving the compound 3 in tetrahydrofuran and then performing catalysis with concentrated sulfuric acid, and performing reflux stirring overnight treatment to obtain a compound 4, dissolving the compound 4 into dichloromethane and water, adding sodium bicarbonate and TEMPO, slowly adding sodium hypochlorite at 0DEG C, raising the temperature to room temperature, and conducting stirring overnight treatment to obtain a compound 5. The method has the characteristics of easily available raw materials and low production cost, each process step is simple and easy to treat, the yield ofthe whole route reaches 43% or above, industrial production is easy to realize, and a basis is provided for industrialization of remdesivir and subsequent derivatives thereof.

COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF AS INHIBITORS OF RAN GTPASE

-

, (2019/04/09)

Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.

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