64682-29-7Relevant articles and documents
Interactions in Crystals: The Dimorphism of (2-Pyridyl)(2-pyrimidyl)amine
Bock, Von Hans,Sch?del, Holger,N?ther, Christian,Butensch?n, C.N. Frauke
, p. 593 - 605 (1997)
Preceding structural studies of 2-aminopyridine derivatives prove that they form polymorphic H-pair-bonded dimers, and, therefore, (2-pyridyl)(2-pyrimidyl)amine has been crystallized under different conditions. Two different monoclinic modifications are characterized by their crystal structures of the same space group P21/c: form I exhibits the well known herringbone motif and form II the sandwich-herringbone one. Both modifications contain almost identical planar, H-pair-bridged molecular dimers. Crystals of form I are readily obtained from any solvent, whereas those of form II result either on fast evaporation of a Et2O solution or by resolidification of the melt. Differential thermal analysis (DTA) and crystallization experiments at different temperatures prove, for both modifications, no transitions in the temperature range between -25° and the melting point at 152° and, therefore, the system should be monotropic. The structural and thermodynamic aspects of the (2-pyridyl)(2-pyrimidyl)amine dimorphism are discussed in comparison to those of the trimorphism observed for di(2-pyridyl)amine.
Sequential amination of heteroaromatic halides with aminopyridine 1-oxides and their N-protected derivatives based on novel aza-Smiles rearrangement
Wolinska, Ewa
, p. 227 - 232 (2013/05/09)
The SNAr and Pd-catalyzed amination of chloro derivatives of azines, diazines, and triazines with 2-aminopyridine 1-oxides and their N-protected derivatives was described.