64693-47-6

Basic information

• Product Name: 4-(ETHYL-METHYL-AMINO)-BENZALDEHYDE
• Synonyms: 4-(ETHYL-METHYL-AMINO)-BENZALDEHYDE;4-[ethyl(methyl)amino]benzaldehyde(SALTDATA: FREE)
• CAS NO: 64693-47-6
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• Mol File: 64693-47-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 282°C at 760 mmHg
• Flash Point: 106.5°C
• Appearance: /
• Density: 1.048g/cm³
• Vapor Pressure: 0.00344mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 4-(ETHYL-METHYL-AMINO)-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(ETHYL-METHYL-AMINO)-BENZALDEHYDE(64693-47-6)
• EPA Substance Registry System: 4-(ETHYL-METHYL-AMINO)-BENZALDEHYDE(64693-47-6)

Safety Data

• Hazardous Substances Data: 64693-47-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H13NO/c1-3-11(2)10-6-4-9(8-12)5-7-10/h4-8H,3H2,1-2H3

Upstream product

• 624-78-2 N-Ethylmethylamine 
• 459-57-4 4-fluorobenzaldehyde 
• 613-97-8 N-methyl-N-ethylaniline 
• 68-12-2 N,N-dimethyl-formamide 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 1402063-05-1 2-(4-(ethyl(methyl)amino)benzylidene)-6-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one hydrochloride 
• 1402063-12-0 2-(4-(ethyl(methyl)amino)benzylidene)-5,6-dihydroxy-2,3-dihydro-1H-inden-1-one 4-methylbenzene-1-sulfonic acid 
• 1333325-69-1 1,3,5,7-tetramethyl-2,6-bis(2-methoxycarbonylethyl)-8-[4-(N-ethyl-N-methylamino)phenyl]-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene 
• 1333325-70-4 1,3,5,7-tetramethyl-2,6-bis(2-carboxyethyl)-8-[4-(N-ethyl-N-methylamino)phenyl]-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene 
• 1333325-62-4 C₄₀H₅₃BF₂N₈O₈ 
• 95548-98-4 (E)-2,3-Bis-[4-(ethyl-methyl-amino)-phenyl]-but-2-enedinitrile 
• 95549-03-4 2,3-Bis-[4-(ethyl-methyl-amino)-phenyl]-succinonitrile 
• 94682-39-0 N,N'-diethyl-N,N'-dimethyl-trans-stilbene-4,4'-diyldiamine 
• 119187-32-5 N-ethyl-4-(trans-2-[4]quinolyl-vinyl)-N-methyl-aniline 

Relevant articles and documents

Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease

A series of indanone derivatives were designed, synthesized, and tested using a variety of assays to assess their potential as anti-Alzheimer's disease (AD) agents. The investigations assessed the activities of the agents for the inhibition of cholinesterases (AChE and BuChE), the inhibition of amyloid beta (Aβ) self-assembly, and the catalysis of the disassembly of preformed Aβ oligomers and measured their antioxidant activities. Our results demonstrate that most of the synthesized compounds demonstrated good inhibitory activity against AChE with IC50 values in the nanomolar range. In particular, compounds 9 (IC50 Combining double low line 14.8 nM) and 14 (IC50 Combining double low line 18.6 nM) exhibited markedly higher inhibitory activities than tacrine and similar activities to donepezil. In addition, 9 and 14 significantly inhibited Aβ aggregation (inhibition rates of 85.5% and 83.8%, respectively), catalysed the disaggregation of Aβ fibrils generated by self-induced Aβ aggregation, and exhibited antioxidant activity. Furthermore, these two compounds can cross the blood-brain barrier (BBB) in vitro. These properties highlight the potential of these new compounds to be developed as multi-functional drugs for the treatment of Alzheimer's disease.

Efficiency of the Vilsmeier-Haack method in the synthesis of p-aminobenzaldehydes

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