6479-18-1

Basic information

• Product Name: 1-methylquinoxalin-2(1H)-one
• Synonyms: 1-Methylquinoxalin-2(1H)-one; 2(1H)-quinoxalinone, 1-methyl-
• CAS NO: 6479-18-1
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.1726
• Mol File: 6479-18-1.mol
• Article Data: 42

Chemical Properties

• Boiling Point: 296.8°C at 760 mmHg
• Flash Point: 133.3°C
• Density: 1.21g/cm³
• Vapor Pressure: 0.0014mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 1-methylquinoxalin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methylquinoxalin-2(1H)-one(6479-18-1)
• EPA Substance Registry System: 1-methylquinoxalin-2(1H)-one(6479-18-1)

Safety Data

• Hazardous Substances Data: 6479-18-1(Hazardous Substances Data)

Usage

General Description

1-methylquinoxalin-2(1H)-one is a chemical compound with the molecular formula C9H8N2O. It is a quinoxaline derivative, which is a heterocyclic compound containing a benzene ring fused to a pyrazine ring. 1-methylquinoxalin-2(1H)-one is commonly used in organic synthesis and pharmaceutical research due to its unique structure and potential biological activities. It has been studied for its potential anticancer, anti-inflammatory, and antimicrobial properties. It is also used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Additionally, 1-methylquinoxalin-2(1H)-one has been identified as a potential component in the development of new drugs for the treatment of various diseases.

Upstream product

• 1196-57-2 quinoxalin-2⁽¹⁾-one 
• 1719-57-9 Chloro(chloromethyl)dimethylsilane 
• 186581-53-3 diazomethane 
• 1196-57-2 2-hydroxyquinoxaline 
• 1239573-75-1 2-chloro-N-(2-iodophenyl)-N-methylacetamide 
• 74-88-4 methyl iodide 
• 74-89-5 methylamine 
• 4760-34-3 N-methyl-1,2-phenylenediamine 
• 6295-06-3 butyl glyoxalate 
• 77-78-1 dimethyl sulfate 
• 14003-34-0 3-methyl-2-oxo-1,2-dihydroquinoxaline 
• 74-87-3 methylene chloride 
• 59564-59-9 1,2,3,4-tetrahydroquinoxalin-2-one 
• 5428-05-7 n-(2-nitrophenyl)glycine ethyl ester 

Downstream Products

• 112828-57-6 4-Methyl-1-phenyl-2,2a-dihydro-1H,4H-azeto[1,2-a]quinoxalin-3-one 
• 37141-64-3 1-methyl-3-(2-oxo-cyclohexyl)-1H-quinoxalin-2-one 
• 85728-46-7 3-[2-(3-Bromo-phenyl)-2-oxo-ethyl]-1-methyl-1H-quinoxalin-2-one 
• 22298-78-8 1-methyl-3-(2-oxo-2-phenyl-ethyl)-1H-quinoxalin-2-one 
• 20934-51-4 1,2-Dihydro-3-hydroxy-1-methyl-2-oxo-chinoxalin 
• 1224881-56-4 3-(5-benzyloxy-1H-indol-3-yl)-1-methylquinoxalin-2-one 
• 2048-37-5 1-methyl-3-phenylquinoxalin-2(1H)-one (3a) 
• 25160-82-1 1-methyl-3-phenyl-3,4-dihydroquinoxalin-2(1H)-one 
• 37413-49-3 3-(2-methoxyphenyl)-1-methylquinoxalin-2(1H)-one 
• 1057224-07-3 3-(4-fluorophenyl)-1-methylquinoxalin-2(1H)-one 

Relevant articles and documents

Photoinitiated Multicomponent Anti-Markovnikov Alkoxylation over Graphene Oxide

The development of graphene oxide–based heterogeneous materials with an economical and environmentally–friendly manner has the potential to facilitate many important organic transformations but proves to have few relevant reported reactions. Herein, we explore the synergistic role of catalytic systems driven by graphene oxide and visible light that form nucleophilic alkoxyl radical intermediates, which enable an anti-Markovnikov addition exclusively to the terminal alkenes, and then the produced benzyl radicals are subsequently added with N–methylquinoxalones. This photoinduced cascade radical difunctionalization of olefins offers a concise and applicable protocol for constructing alkoxyl–substituted N–methylquinoxalones.

Application of biomass-supported copper-catalyzed three-component reaction in preparation of fluorine-containing drugs

The invention relates to an application of a biomass-supported copper-catalyzed three-component reaction in preparation of a fluorine-containing drug. The indole and its derivatives and are synthesized 3 - (2 - (trifluoromethyl) - indo -3 -yl) quinoxaline -2 - ketone derivatives by one-pot synthesis by three-component one-pot method. To the invention, the heterogeneous biological substance carried copper catalyst is adopted to catalyze the reaction, and the problems that a traditional homogeneous catalyst cannot be recovered, metal residues are left and the like are solved. 3 - (2 - (Trifluoromethyl) - indo -3 -yl) quinoxaline -2 - ketone compounds with different substituents are expanded, and the biomass supported copper catalyst can be cyclically and catalytically reacted.

Synthesis of (E)-Quinoxalinone Oximes through a Multicomponent Reaction under Mild Conditions

Herein, a novel method for the gram-scale synthesis of (E)-quinoxalinone oximes through a multicomponent reaction under mild conditions is described. Such a transformation was performed under transition-metal-free conditions, affording (E)-oximes in a moderate-to-good yield through recrystallization. Our methodology demonstrates a successful combination of a Mannich-type reaction and radical coupling, providing a green and practical approach for the synthesis of potentially bioactive quinoxalinone-containing molecules.