64869-63-2Relevant articles and documents
Two subtle amino acid changes in a transaminase substantially enhance or invert enantiopreference in cascade syntheses
Skalden, Lilly,Peters, Christin,Dickerhoff, Jonathan,Nobili, Alberto,Joosten, Henk-Jan,Weisz, Klaus,H?hne, Matthias,Bornscheuer, Uwe T.
, p. 1041 - 1045 (2015)
Amine transaminases (ATAs) are powerful enzymes for the stereospecific production of chiral amines. However, the synthesis of amines incorporating more than one stereocenter is still a challenge. We developed a cascade synthesis to access optically active
Synthesis of (1R,3R)-1-amino-3-methylcyclohexane by an enzyme cascade reaction
Skalden, Lilly,Peters, Christin,Ratz, Lukas,Bornscheuer, Uwe T.
, p. 7207 - 7211 (2016/10/26)
Amine transaminases (ATAs) are powerful enzymes for the synthesis of chiral amines. Although the request for amines with more than one chiral center is increasing, their synthesis is still challenging. Here we show a casacde reaction combining an enoate r
