6512-83-0

Basic information

• Product Name: BIS(2-CARBOXYPHENYL)DISELENIDE
• Synonyms: BIS(2-CARBOXYPHENYL)DISELENIDE;2,2'-Diselenobisbenzoic acid;2,2'-Diselenodibenzoic acid;Diseleno salicylic acid
• CAS NO: 6512-83-0
• Molecular Formula: C₁₄H₁₀O₄Se₂
• Molecular Weight: 400.1468
• Mol File: 6512-83-0.mol
• Article Data: 67

Chemical Properties

• Melting Point: 297°C (rough estimate)
• Boiling Point: 585.7±60.0 °C(Predicted)
• Appearance: /solid
• PKA: 2.96±0.36(Predicted)
• CAS DataBase Reference: BIS(2-CARBOXYPHENYL)DISELENIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(2-CARBOXYPHENYL)DISELENIDE(6512-83-0)
• EPA Substance Registry System: BIS(2-CARBOXYPHENYL)DISELENIDE(6512-83-0)

Safety Data

• Hazardous Substances Data: 6512-83-0(Hazardous Substances Data)

Usage

Safety Profile

Poison by intraperitoneal and intravenous routes. When heated to decomposition it emits toxic fumes of Se

Upstream product

• 17333-86-7 o-Carboxybenzenediazonium 
• 55038-90-9 bis(2-carboxamidophenyl) diselenide 
• 118-92-3 anthranilic acid 
• 1441-85-6 2-(chloroseleno)benzoyl chloride 
• 1441-91-4 S-phenyl 2-[(phenylthio)seleno]benzoate 
• 87-25-2 2-ethoxycarbonylaniline 
• 1441-78-7 ethyl 2-selenocyanatobenzoate 
• 134-20-3 2-carbomethoxyaniline 
• 136918-14-4 phthalimide 
• 2099-63-0 anthranilic acid hydrochloride 
• 108-24-7 acetic anhydride 
• 4661-46-5 2-carboxybenzene diazonium chloride 
• 1441-84-5 2-selenocyanato-benzoyl chloride 
• 3930-83-4 o-iodobenzamide 

Downstream Products

• 108059-83-2 bis(2-methoxycarbonylphenyl) diselenide 
• 6547-08-6 2-(methylseleno)benzoic acid 
• 126543-40-6 2-(benzylselenyl)benzoic acid 
• 1441-85-6 2-(chloroseleno)benzoyl chloride 
• 105893-07-0 2,2’-diselanediyldibenzoyl chloride 
• 6518-77-0 2-(hydroxymethyl)phenyl methyl selenide 
• 92745-06-7 2-hydroselenobenzoic acid 
• 865855-24-9 allyl 2-carboxyphenyl selenide 
• 1049731-35-2 C₁₀H₈O₂Se 
• 39857-38-0 2-(carboxymethylselanyl)benzoic acid 
• 1049731-41-0 2-(phenacylselenyl)benzoic acid 
• 1049731-42-1 2-(4'-bromophenacylselenyl)benzoic acid 
• 617688-67-2 C₁₁H₁₂O₂Se 
• 217798-39-5 2,2'-(1,2-ethanediyl)bis(1,2-benzoselenazol-3[2H]-one) 

Relevant articles and documents

Synthesis and biological evaluation of new nitrogen-containing diselenides

The antioxidant properties of organoselenium compounds have been extensively investigated with the aim of developing new drugs, since oxidative stress is responsible for a variety of chronic human diseases. Herein, we reported the synthesis of new nitrogen-containing diselenides by a simple and efficient synthetic route. The products were obtained in good to excellent yields and their identification and characterization were achieved by NMR and HRMS techniques. The new derivatives may represent promising structures with different biological activities, which can act against oxidative stress through diverse mechanisms of action. The glutathione peroxidase-like assay (GPx-like activity) of the new synthesized compounds indicated that they reduced H2O2to water at the expense of PhSH. The best results were obtained with diselenide 2b, which was 9 times more active than the standard organoselenium drug ebselen and, in contrast, this compound was not reduced by hepatic TrxR. All of the new compounds inhibited Fe(II)-induced TBARS.

Benzoselenazolone compound and application thereof and bactericide

The invention relates to the field of antifungal drugs, and discloses a benzoselenazolone compound and application thereof and a bactericide, and the benzoselenazolone compound has a structural general formula shown in a formula (I). The benzoselenazolone compound provided by the invention can take candida albicans fructose-1, 6-diphosphate aldolase (Ca-FBA-II) as a target spot to inhibit the activity of the candida albicans fructose 1, 6-diphosphate aldolase (Ca-FBA-II), and has a good resistance effect on drug-resistant bacteria generated by taking cytochrome P450 as an action target.

Synthesis of new alkylated and methoxylated analogues of ebselen with antiviral and antimicrobial properties

A series of new mono and disubstituted alkylated and methoxylated benzisoselanzol-3(2H)-ones and bis(2carbamoylaryl)diselenides were prepared in yields ranging from 55% to 95% starting from anthranilic acid and were evaluated for antiviral and antimicrobial activity. The compounds exhibited antiviral activity against Human herpes virus 1 and Encephalomyocarditis virus as well as antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Candida albicans. R1 O O R1 COOH N N R2 H Se R2 NH2 Se 2 R1, R2 = Me, OMe, Cl, t-Bu, H.