65347-55-9

Basic information

• Product Name: 3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE
• Synonyms: 3-(1,2,3,6-TETRAHYDRO-4-PYRINYL)-1H-INDOLE;3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOL-5-OL;3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE;4-(1H-Indol-3-yl)-1,2,3,6-tetrahydropyridine;1H-Indole, 3-(1,2,3,6-tetrahydro-4-pyridinyl)-;3-(1,2,3,6-Tetrahydro-4-pyridyl)indole
• CAS NO: 65347-55-9
• Molecular Formula: C₁₃H₁₄N₂
• Molecular Weight: 198.26
• Mol File: 65347-55-9.mol
• Article Data: 20

Chemical Properties

• Melting Point: 177-182°C
• Boiling Point: 400.4 °C at 760 mmHg
• Flash Point: 195.9 °C
• Appearance: /Solid
• Density: 1.163 g/cm³
• Vapor Pressure: 2.42E-09mmHg at 25°C
• Refractive Index: 1.691
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE(65347-55-9)
• EPA Substance Registry System: 3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE(65347-55-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 65347-55-9(Hazardous Substances Data)

Usage

General Description

3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole is a chemical compound that belongs to the class of indole derivatives. It is a small molecule that contains both a tetrahydropyridine moiety and an indole ring, making it a heterocyclic compound. 3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE may have potential biological activities and therapeutic applications, as indole derivatives are known for their diverse pharmacological properties, including anti-inflammatory, anticancer, and antimicrobial activities. The specific biological activities and potential uses of 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole would depend on further research and investigation into its properties and interactions with biological systems.

InChI:InChI=1/C13H14N2O/c16-10-1-2-13-11(7-10)12(8-15-13)9-3-5-14-6-4-9/h1-3,7-8,14-16H,4-6H2

Upstream product

• 120-72-9 indole 
• 40064-34-4 4-piperidone monohydrochloride monohydrate 
• 1336-21-6 ammonium hydroxide 
• 41661-47-6 piperidin-4-one 
• 40064-34-4 piperidine-4,4-diol hydrochloride 
• 41979-39-9 4-piperidone hydrochloride 

Downstream Products

• 695211-85-9 4-(1H-indol-3-yl)-piperidine-1-carboxylic acid (4-dimethylamino-4-phenyl-cyclohexylmethyl)-amide 
• 60155-63-7 4-(1H-indol-3-yl)piperidinium chloride 
• 72826-65-4 (propyl-1 tetrahydro-1,2,3,6 pyridinyl-4)-3 1H-indole (chlorohydrate) 
• 72808-69-6 3-(1-pentyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole hydrochloride 
• 460353-65-5 SSA-426 

Relevant articles and documents

Inhibitors of the serotonin transporter protein (SERT): The design and synthesis of biotinylated derivatives of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H- indoles. High-affinity serotonergic ligands for conjugation with quantum dots

There is a growing demand for compounds with specificity for the serotonin transporter protein (SERT) that can be conjugated to cadmium selenide/zinc sulfide core shell nanocrystals. This letter describes the design and synthesis of two different biotinylated SERT antagonists that can be attached to streptavidin-coated cadmium selenide/zinc sulfide core shell nanocrystals.

Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1

A series of 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives was synthesized and their biological activity was evaluated. The chemical structures of the newly prepared compounds were confirmed by 1H NMR, 13C NMR and ESI-HRMS spectra data. All tested compounds proved to be potent 5-HT1A receptor and serotonin transporter protein (SERT) ligands. Among them, compounds 15, 18, 19 and 30 showed significant affinity for 5-HT1A and SERT. Computer docking simulations carried out for compounds 15, 31 and 32 to models of 5-HT1A receptor and SERT confirm the results of biological tests. Due to high affinity for the 5-HT1A receptor and moderate affinity for SERT, compounds 31, 32, 35, and 37 were evaluated for their affinity for D2L, 5-HT6, 5-HT 7 and 5-HT2A receptors. In vivo tests, in turn, resulted in determining the functional activity of compounds 15, 18, 19 and 30 to the 5-HT1A receptor. The results of these tests indicate that all of the ligands possess properties characteristic of 5-HT1A receptor agonists.

DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS

Autophagy inducing compounds, methods of their preparation and use, and kits containg said compounds are disclosed herein.