65355-32-0

Basic information

• Product Name: trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid
• Synonyms: (TRANS,TRANS)-4'-PROPYL-[1,1'-BICYCLOHEXYL]-4-CARBOXYLIC ACID;4'-PROPYL-BICYCLOHEXYL-4-CARBOXYLIC ACID;Trans-4-n-propyl cyclohexyl-cyclohexane-4"-carboxylic acid;Trans-4-Propyl-(1,1-Bicyclohexyl)-4-CarboxylicAcid,3HhaC16H28O2;4-trans-(4-trans-Propylcyclohexyl)-cyclohexancarbonsure;trans-4-（trans-4’-propylcyclohexyl）cyclohexane carboxylic acid;trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid;3HHA
• CAS NO: 65355-32-0
• Molecular Formula: C₁₆H₂₈O₂
• Molecular Weight: 252.39
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Liqiud crystal intermediates
• Mol File: 65355-32-0.mol

Chemical Properties

• Melting Point: 200℃
• Boiling Point: 370.9±10.0 °C(Predicted)
• Appearance: /
• Density: 0.998±0.06 g/cm3(Predicted)
• Vapor Pressure: 0Pa at 25℃
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Methanol (Sparingly)
• PKA: 4.90±0.10(Predicted)
• CAS DataBase Reference: trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid(65355-32-0)
• EPA Substance Registry System: trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid(65355-32-0)

Safety Data

• Hazardous Substances Data: 65355-32-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Industry:
trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid is used as a precursor for the preparation of bihexyl derivatives, which are important compounds in various chemical applications.
Used in Liquid Crystal Industry:
trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid is used as an intermediate in the synthesis of liquid crystals, which are widely used in display technologies and other electronic devices.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, given its chemical structure and properties, trans-4'-Propyl-(1,1'-bicyclohexyl)-4-carboxylic acid could potentially be used as a building block for the development of pharmaceutical compounds, taking advantage of its unique molecular structure and reactivity.

Flammability and Explosibility

Notclassified

Upstream product

• 65355-29-5 4-(trans-4'-propylcyclohexyl)-benzoic acid 
• 65355-35-3 trans,trans-4'-propyl-[1,1'-bicyclohexyl]-4-carbonitrile 

Downstream Products

• 494213-18-2 4-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}benzenamine 
• 494213-17-1 1-{difluoro[(trans,trans)-4'-propyl(1,1'-bicyclohexyl)-4-yl]methoxy}-4-nitrobenzene 
• 82562-85-4 4-Hydroxymethyl-4'-propylbicyclohexyl 
• 65355-35-3 trans,trans-4'-propyl-[1,1'-bicyclohexyl]-4-carbonitrile 

Relevant articles and documents

Improved synthesis of trans-4-alkylcyclohexane carboxylic acids

Several stereomerically pure amino acid derivatives containing the N-terminal trans-4-alkylcyclohexanoyl fragment were obtained. Hydrogenation of 4-alkylbenzoic acids in the presence of a special Ru-Ni/C catalytic system and isomerization of the resulting mixture of trans- and cis-isomers of 4-alkylcyclohexanecarboxylic acids were used as the key steps. The stereomeric configuration of all compounds was confirmed by 1H NMR spectroscopy. The compounds obtained possess a broad biological activity potential and are useful intermediates in the synthesis of stereomerically pure modified peptides.

The Synthesis and Liquid Crystal Behavior of p-Benzotrifluoride Compounds III

Two compounds with the general structure R-CY-CY-CH2-CH2-Ph-CF3 were synthesized where CY is a 1,4-disubstituted trans cyclohexyl ring, and R is a n-alkyl group.The synthesis procedure is discussed and structural assignments confirmed by proton and carbon 13 NMR spectroscopy.Liquid crystal behavior was evaluated by DTA and polarized microscope.We discovered that the two compounds have smectic and nematic phases and can be used in fast switching liquid crystal mixtures.

HYDROGENATION OF p-(trans-4-ALKYLCYCLOHEXYL) BENZOIC ACIDS IN ALKALINE CONDITIONS.

In a previous work it was shown that reduction of alkylbenzoic acids by sodium in amyl alcohol gives a higher percentage content of the trans isomer than other methods because of subsequent isomerization of the resultant mixture of cis and trans isomers of alkylcyclohexanecarboxylic acids under the influene of soidum alcoholate. In this work this method was used for reduction of p-(trans-4-alkylcyclohexyl)benzoic acids (II), the liquid-crystal properties of which are conclusive evidence of trans-1,4-diequatorial substitution of the cyclohexane group. Experimental evidence shows that reduction of p-(4-trans-butyclohexyl) benzoic acid (II) with Na/C//5H//1//1OH leads to formation of 4-trans-(4-trans-butylcyclohexyl) cyclohexaneacarboxylic left bracket (I)-trans right bracket and 4-cis-(4-trans-butylcyclohexyl) cyclohexanecarboxylic left bracket (I)-cis right bracket acids; in the course of reduction with NaOC//5H//1//1 the latter of these acids undergoes isomerization to (I)-trans to give an equilibrium mixture consisting of 92% (I)-trans and 8% (I)-cis.