65355-33-1Relevant articles and documents
Improved synthesis of trans-4-alkylcyclohexane carboxylic acids
Bazurin, Alexey A.,Krasnikov, Sergey V.,Obuchova, Tatiana A.,Danilova, Angelina S.,Balakin, Konstantin V.
, p. 6669 - 6672 (2007/10/03)
Several stereomerically pure amino acid derivatives containing the N-terminal trans-4-alkylcyclohexanoyl fragment were obtained. Hydrogenation of 4-alkylbenzoic acids in the presence of a special Ru-Ni/C catalytic system and isomerization of the resulting mixture of trans- and cis-isomers of 4-alkylcyclohexanecarboxylic acids were used as the key steps. The stereomeric configuration of all compounds was confirmed by 1H NMR spectroscopy. The compounds obtained possess a broad biological activity potential and are useful intermediates in the synthesis of stereomerically pure modified peptides.
The Synthesis and Liquid Crystal Behavior of p-Benzotrifluoride Compounds III
Liang, J. C.,Cross, J. O.,Chen, L.
, p. 199 - 206 (2007/10/02)
Two compounds with the general structure R-CY-CY-CH2-CH2-Ph-CF3 were synthesized where CY is a 1,4-disubstituted trans cyclohexyl ring, and R is a n-alkyl group.The synthesis procedure is discussed and structural assignments confirmed by proton and carbon 13 NMR spectroscopy.Liquid crystal behavior was evaluated by DTA and polarized microscope.We discovered that the two compounds have smectic and nematic phases and can be used in fast switching liquid crystal mixtures.
HYDROGENATION OF p-(trans-4-ALKYLCYCLOHEXYL) BENZOIC ACIDS IN ALKALINE CONDITIONS.
Karamysheva,Geivandova,Torgova,Kovshev,Betnev,Obukhova
, p. 1455 - 1459 (2007/10/02)
In a previous work it was shown that reduction of alkylbenzoic acids by sodium in amyl alcohol gives a higher percentage content of the trans isomer than other methods because of subsequent isomerization of the resultant mixture of cis and trans isomers of alkylcyclohexanecarboxylic acids under the influene of soidum alcoholate. In this work this method was used for reduction of p-(trans-4-alkylcyclohexyl)benzoic acids (II), the liquid-crystal properties of which are conclusive evidence of trans-1,4-diequatorial substitution of the cyclohexane group. Experimental evidence shows that reduction of p-(4-trans-butyclohexyl) benzoic acid (II) with Na/C//5H//1//1OH leads to formation of 4-trans-(4-trans-butylcyclohexyl) cyclohexaneacarboxylic left bracket (I)-trans right bracket and 4-cis-(4-trans-butylcyclohexyl) cyclohexanecarboxylic left bracket (I)-cis right bracket acids; in the course of reduction with NaOC//5H//1//1 the latter of these acids undergoes isomerization to (I)-trans to give an equilibrium mixture consisting of 92% (I)-trans and 8% (I)-cis.
