6576-05-2

Basic information

• Product Name: 1-(4-FLUORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE
• Synonyms: 4-FLUOROPHENYL-4-PYRIDYLMETHYL KETONE;AKOS 91212;1-(4-FLUORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE;4-fluorophenyl-4-pyridylmethyl;1-(4-fluorophenyl)-2-(pyridin-4-yl)ethan-1-one;Ethanone, 1-(4-fluorophenyl)-2-(4-pyridinyl)-;1-(4-FLUORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE(WXG03045)
• CAS NO: 6576-05-2
• Molecular Formula: C₁₃H₁₀FNO
• Molecular Weight: 215.22
• Product Categories: pharmacetical;API intermediates
• Mol File: 6576-05-2.mol
• Article Data: 33

Chemical Properties

• Melting Point: 94-97 °C
• Boiling Point: 362.6 °C at 760 mmHg
• Flash Point: 173.1 °C
• Appearance: /
• Density: 1.201 g/cm³
• Vapor Pressure: 1.91E-05mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 5.18±0.10(Predicted)
• CAS DataBase Reference: 1-(4-FLUORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE(6576-05-2)
• EPA Substance Registry System: 1-(4-FLUORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE(6576-05-2)

Safety Data

• Hazardous Substances Data: 6576-05-2(Hazardous Substances Data)

Usage

General Description

1-(4-fluoro-phenyl)-2-pyridin-4-yl-ethanone, also known as furylfentanyl, is a chemical compound with a molecular formula C14H10FNO. It belongs to the class of pyridine derivatives and is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. This chemical is characterized by its pyridine ring and ketone group with a fluorine-substituted phenyl ring attached. It has applications in the field of medicinal chemistry and chemical research, and it is important to handle and store this compound with precaution due to its potential health hazards.

InChI:InChI=1/C13H10FNO/c14-12-3-1-11(2-4-12)13(16)9-10-5-7-15-8-6-10/h1-8H,9H2

Upstream product

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• 403-33-8 methyl 4-flurobenzoate 

Downstream Products

• 145021-97-2 1-<(tert-butyloxy)carbonyl>-4-(2-(4-fluorophenyl)-2-oxoethyl)piperidine 
• 512786-09-3 2-amino-3-ethoxycarbonyl-4-(4-fluorophenyl)-5-(4-pyridyl)thiophene 
• 888319-03-7 1-(4-fluorophenyl)-2-(pyridin-4-yl)pent-4-en-1-one 
• 166895-16-5 N-[1-(4-fluorophenyl)-2-(pyridin-4-yl)ethylidene]hydroxylamine 
• 216504-75-5 4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyridine 
• 271577-22-1 1-(4-fluorophenyl)-3,3-bis(methylthio)-2-pyridin-4-ylprop-2-en-1-one 
• 888319-05-9 4-(4-fluorophenyl)-4-oxo-3-(pyridin-4-yl)butanal 
• 888319-07-1 5-(4-fluorophenyl)-4-(pyridin-4-yl)pyrrole-2-carbaldehyde 
• 888318-78-3 [5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-acetic acid methyl ester 
• 888318-89-6 {2-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-ethyl}-dimethyl-amine 
• 888318-92-1 5-(4-fluoro-phenyl)-2,5-dioxo-4-pyridin-4-yl-pentanoic acid ethyl ester 
• 888318-85-2 2-[5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-N,N-dimethyl-acetamide 
• 888318-83-0 [5-(4-fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-acetic acid 
• 888319-14-0 5'-(4-fluoro-phenyl)-4'-pyridin-4-yl-2,3,4,5-tetrahydro-1H,1'H-[2,2']bipyrrolyl 

Relevant articles and documents

NEW COMPOUNDS FOR TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION

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Ligand-protein interactions of selective casein kinase 1δ inhibitors

Casein kinase 1δ (CK1δ) and 1ε (CK1ε) are believed to be necessary enzymes for the regulation of circadian rhythms in all mammals. On the basis of our previously published work demonstrating a CK1ε-preferring compound to be an ineffective circadian clock modulator, we have synthesized a series of pyrazole-substitued pyridine inhibitors, selective for the CK1δ isoform. Additionally, using structure-based drug design, we have been able to exploit differences in the hinge region between CK1δ and p38 to find selective inhibitors that have minimal p38 activity. The SAR, brain exposure, and the effect of these inhibitors on mouse circadian rhythms are described. The in vivo evaluation of these inhibitors demonstrates that selective inhibition of CK1δ at sufficient central exposure levels is capable of modulating circadian rhythms.