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6578-87-6

6578-87-6

6578-87-6

Identification

Synonyms:Phenol,p-[N-(5-phenyl-1,3,4-thiadiazol-2-yl)formimidoyl]-(7CI,8CI); NSC 88503

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Chemical Properties

  • Boiling Point: 472.1°Cat760mmHg

  • Flash Point:239.3°C

  • Density: 1.44g/cm3

  • Vapor Pressure: 4.38E-09mmHg at 25°C

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 7 Articles be found

Synthesis, Characterization and Biological Evaluation of Some Novel Azo-Imine Compounds

Nair, Smitha,Palanisamy, P.,Sunitha, K.

, p. 663 - 667 (2022/02/22)

The oxidative cyclization of thiosemicarbazone (III) synthesized from reaction between substituted aryl aldehydes (I) with thiosemicarbazide (II) was done using ferric chloride as oxidative agent to get 2-amino-5-phenyl-1,3,4-thiadiazole (IV). 2-Amino-5-phenyl-1,3,4-thiadiazole was introduced in condensation reactions with substituted aldehydes to obtain benzylidene imine derivatives (VI)1-5. Further these were treated with sulphanilic acid to give new 2-{[5-phenyl-1,3,4-thiadiazole-2-imino] substituted benzene}diazenyl benzene sulfonic acid derivatives (VII)1-5. These derivatives were further characterized by FT-IR, 1H NMR and 13C NMR spectral studies and were screened for antibacterial, antifungal and antioxidant activities.

Synthesis and evaluation of some novel 1,3,4-thiadiazoles for antidiabetic activity

Pattan,Kittur,Sastry,Jadav,Thakur,Madamwar,Shinde

, p. 615 - 618 (2011/06/21)

A new series of 1,3,4-thiadiazole derivatives are synthesized and the structures of these compounds have been established on the basis of spectral and elemental analysis. All the compounds are evaluated for antidiabetic activity on albino rats. Most of th

Electronic Spectra and Acidity Constants of Hetero-Aromatic Schiff Bases Derived from 2-Amino-5-phenyl-1,3,4-Thiodiazole and Various Aromatic Aldehydes

Mahmoud, M. R.,Hamide, R. Abdel,Goad, F. Abdel

, p. 551 - 560 (2007/10/02)

The different absorption bands observed in the UV and visible electronic spectra of some arylidene 2-amino-1,3,4-thiodiazole are assigned to the possible electronic transitions.This is made in the light of investigating the spectra of the compounds in pur

Process route upstream and downstream products

Process route

1-benzylidene thiosemicarbazide
1627-73-2

1-benzylidene thiosemicarbazide

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol
6578-87-6

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: iron(III) chloride / water / 0.05 h / Microwave irradiation; Sonication; Green chemistry
2: water / 0.05 h / Microwave irradiation; Sonication; Green chemistry
With iron(III) chloride; In water;
2-amino-5-phenyl-1,3,4-thiadiazole
2002-03-1

2-amino-5-phenyl-1,3,4-thiadiazole

4-hydroxy-benzaldehyde
123-08-0,65581-83-1

4-hydroxy-benzaldehyde

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol
6578-87-6

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol

Conditions
Conditions Yield
In water; for 0.05h; Microwave irradiation; Sonication; Green chemistry;
89%
for 0.05h; Microwave irradiation;
70%
at 150 ℃;
56%
With acetic acid; In methanol; at 25 ℃; Kinetics; Mechanism; Thermodynamic data; further temperatures, further object of study: activation energy;
In ethanol;
With piperidine; In ethanol; for 4h; Heating;
With piperidine; In ethanol; Heating;
With piperidine; In ethanol; for 2h; Heating;
With acetic acid; In ethanol; for 6h; Reflux;
C<sub>8</sub>H<sub>9</sub>N<sub>3</sub>S

C8H9N3S

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol
6578-87-6

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: iron(III) chloride / water / 0.75 h / 80 - 90 °C
2: acetic acid / ethanol / 6 h / Reflux
With iron(III) chloride; acetic acid; In ethanol; water;
benzaldehyde
100-52-7

benzaldehyde

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol
6578-87-6

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: ethanol; water
2: iron(III) chloride / water / 0.75 h / 80 - 90 °C
3: acetic acid / ethanol / 6 h / Reflux
With iron(III) chloride; acetic acid; In ethanol; water;
benzoic acid
65-85-0,8013-63-6

benzoic acid

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol
6578-87-6

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sulfuric acid / 2 h / Reflux
2: 0.05 h / Microwave irradiation
With sulfuric acid;
cerium(III) nitrate hexahydrate

cerium(III) nitrate hexahydrate

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol
6578-87-6

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol

Ce(NO<sub>3</sub>)((C<sub>6</sub>H<sub>5</sub>)C<sub>2</sub>N<sub>2</sub>S(NCHC<sub>6</sub>H<sub>4</sub>(OH)))2(H<sub>2</sub>O)2<sup>(2+)</sup>*2NO<sub>3</sub><sup>(1-)</sup> = [Ce(NO<sub>3</sub>)(C<sub>15</sub>H<sub>11</sub>N<sub>3</sub>SO)2(H<sub>2</sub>O)2][NO<sub>3</sub>]2

Ce(NO3)((C6H5)C2N2S(NCHC6H4(OH)))2(H2O)2(2+)*2NO3(1-) = [Ce(NO3)(C15H11N3SO)2(H2O)2][NO3]2

Conditions
Conditions Yield
In ethanol; soln. of Ce-compd. and soln. of ligand in absolute EtOH mixed; refluxedfor 2 h; ppt. filtered off, washed with EtOH, and dried in vacuo; elem. anal.;
uranyl nirate hexahydrate

uranyl nirate hexahydrate

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol
6578-87-6

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol

UO<sub>2</sub>(NO<sub>3</sub>)((C<sub>6</sub>H<sub>5</sub>)C<sub>2</sub>N<sub>2</sub>S(NCHC<sub>6</sub>H<sub>4</sub>(OH)))2(H<sub>2</sub>O)2<sup>(1+)</sup>*NO<sub>3</sub><sup>(1-)</sup> = [UO<sub>2</sub>(NO<sub>3</sub>)(C<sub>15</sub>H<sub>11</sub>N<sub>3</sub>SO)2(H<sub>2</sub>O)2][NO<sub>3</sub>]
107548-34-5

UO2(NO3)((C6H5)C2N2S(NCHC6H4(OH)))2(H2O)2(1+)*NO3(1-) = [UO2(NO3)(C15H11N3SO)2(H2O)2][NO3]

Conditions
Conditions Yield
In ethanol; soln. of UO2-compd. and soln. of ligand in absolute EtOH mixed; refluxed for 2 h; ppt. filtered off, washed with EtOH, and dried in vacuo; elem. anal.;
thorium(IV) nitrate pentahydrate

thorium(IV) nitrate pentahydrate

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol
6578-87-6

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol

Th(NO<sub>3</sub>)2((C<sub>6</sub>H<sub>5</sub>)C<sub>2</sub>N<sub>2</sub>S(NCHC<sub>6</sub>H<sub>4</sub>(OH)))2(H<sub>2</sub>O)2<sup>(2+)</sup>*2NO<sub>3</sub><sup>(1-)</sup> = [Th(NO<sub>3</sub>)2(C<sub>15</sub>H<sub>11</sub>N<sub>3</sub>SO)2(H<sub>2</sub>O)2][NO<sub>3</sub>]2

Th(NO3)2((C6H5)C2N2S(NCHC6H4(OH)))2(H2O)2(2+)*2NO3(1-) = [Th(NO3)2(C15H11N3SO)2(H2O)2][NO3]2

Conditions
Conditions Yield
In ethanol; soln. of Th-compd. and soln. of ligand in absolute EtOH mixed; refluxedfor 2 h; ppt. filtered off, washed with EtOH, and dried in vacuo; elem. anal.;
indium trichloride trihydrate
22519-64-8

indium trichloride trihydrate

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol
6578-87-6

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol

In(Cl)2((C<sub>6</sub>H<sub>5</sub>)C<sub>2</sub>N<sub>2</sub>S(NCHC<sub>6</sub>H<sub>4</sub>(OH)))2(H<sub>2</sub>O)2<sup>(1+)</sup>*Cl<sup>(1-)</sup> = [In(Cl)2(C<sub>15</sub>H<sub>11</sub>N<sub>3</sub>SO)2(H<sub>2</sub>O)2]Cl
107548-32-3

In(Cl)2((C6H5)C2N2S(NCHC6H4(OH)))2(H2O)2(1+)*Cl(1-) = [In(Cl)2(C15H11N3SO)2(H2O)2]Cl

Conditions
Conditions Yield
In ethanol; soln. of In-compd. and soln. of ligand in absolute EtOH mixed; refluxedfor 2 h; ppt. filtered off, washed with EtOH, and dried in vacuo; elem. anal.;
thorium(IV) nitrate pentahydrate

thorium(IV) nitrate pentahydrate

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol
6578-87-6

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol

Th(NO<sub>3</sub>)2((C<sub>6</sub>H<sub>5</sub>)C<sub>2</sub>N<sub>2</sub>S(NCHC<sub>6</sub>H<sub>4</sub>(OH)))3(H<sub>2</sub>O)2<sup>(2+)</sup>*2NO<sub>3</sub><sup>(1-)</sup> = [Th(NO<sub>3</sub>)2(C<sub>15</sub>H<sub>11</sub>N<sub>3</sub>SO)3(H<sub>2</sub>O)2][NO<sub>3</sub>]2

Th(NO3)2((C6H5)C2N2S(NCHC6H4(OH)))3(H2O)2(2+)*2NO3(1-) = [Th(NO3)2(C15H11N3SO)3(H2O)2][NO3]2

Conditions
Conditions Yield
In ethanol; soln. of Th-compd. and soln. of ligand in absolute EtOH mixed; refluxedfor 2 h; ppt. filtered off, washed with EtOH, and dried in vacuo; elem. anal.;

6578-87-6 Upstream products

6578-87-6 Downstream products

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