65792-05-4 Usage
History
In folk medicine, the whole agrimony was used to stop bleeding and inflammation
sterilization; its rhizome was used to treat intestinal bloody flux, the radical bud to
expelling tenia. The clinical application and pharmacological studies have shown
that agrimony root has a broad spectrum of anthelmintic effect with high activity
and low toxicity.In the early 1970s, the Chinese scientists used lime milk extraction method or
petroleum ether as a solvent to separate the extract from the grass buds and further
extracted the main ingredient, agrimophol . Animal experiments and clinical
applications show that the agrimophol has a broad spectrum of anthelmintic effect
with high efficacy, as well as the function of killing schistosomiasis.The chemical structure of agrimophol was determined, and the synthesis was
realized . It is synthesized from methyl phloroglucinol.Recent studies have shown that agrimophol has a significant anticancer effect .
Indications
Available in the Pharmacopoeia of the People’s Republic of China (1977). Capsules,
suitable for the treatment of tapeworm and trichomonas infection.
Pharmacology
Agrimophol has excellent anthelmintic effect and also can be used for treating
trichomonas enteritis, vaginitis, and other diseases. Pharmacological and clinical
trials have shown that the effect of disinfecting cestode is stronger than that of
niclosamide and bithionol, and the side effects are fewer.Agrimophol can be rapidly oxidized after irradiation and release of ROS such as
H2O2, O2 and OH?. OH? which directly destroy DNA and membrane structure of
tumor cells, leading to irreversible damage to the cells . Compared with the
monotherapy with radiotherapy, combined treatment with agrimophol further
induces 25.1% more cell death of human lung adenocarcinoma cells .
Clinical Use
Agrimophol is clinically used to expel tenia and roundworms and kill schistosomiasis.
Side effects
Fewer adverse effects were observed; occasional nausea, vomiting, dizziness,
cold sweat, or a diarrhea after a half month even can lead to collapse reaction.
Although studies have shown that agrimophol has a more pronounced antitumor
activity, there is no relevant antineoplastic drug available.
Check Digit Verification of cas no
The CAS Registry Mumber 65792-05-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,7,9 and 2 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 65792-05:
(7*6)+(6*5)+(5*7)+(4*9)+(3*2)+(2*0)+(1*5)=154
154 % 10 = 4
So 65792-05-4 is a valid CAS Registry Number.
InChI:InChI=1/C26H34O8/c1-8-10-16(27)17-22(31)15(20(29)13(4)23(17)34-7)11-26(6)24(32)14(5)21(30)18(25(26)33)19(28)12(3)9-2/h12,29-32H,8-11H2,1-7H3/t12-,26+/m1/s1
