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6610-29-3

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6610-29-3 Usage

Chemical Properties

white to almost white crystalline powder

Uses

4-Methyl-3-thiosemicarbazide is used in the analysis of electronic features of sulfur-using high-resolution, low-temperature X-ray diffraction data sets. Further, it acts as an intermediate in organic synthesis.

General Description

4-Methyl-3-thiosemicarbazide is a subject of considerable pharmacological interest owing to its wide range of biological effects.

Flammability and Explosibility

Nonflammable

Check Digit Verification of cas no

The CAS Registry Mumber 6610-29-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,1 and 0 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 6610-29:
(6*6)+(5*6)+(4*1)+(3*0)+(2*2)+(1*9)=83
83 % 10 = 3
So 6610-29-3 is a valid CAS Registry Number.
InChI:InChI=1/C2H7N3OS/c1-7-5-4-2(3)6/h5H,1H3,(H3,3,4,6)

6610-29-3 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (B21138)  4-Methyl-3-thiosemicarbazide, 97%   

  • 6610-29-3

  • 10g

  • 382.0CNY

  • Detail
  • Alfa Aesar

  • (B21138)  4-Methyl-3-thiosemicarbazide, 97%   

  • 6610-29-3

  • 50g

  • 1290.0CNY

  • Detail
  • Alfa Aesar

  • (B21138)  4-Methyl-3-thiosemicarbazide, 97%   

  • 6610-29-3

  • 250g

  • 4534.0CNY

  • Detail
  • Aldrich

  • (130060)  4-Methyl-3-thiosemicarbazide  97%

  • 6610-29-3

  • 130060-10G

  • 332.28CNY

  • Detail
  • Aldrich

  • (130060)  4-Methyl-3-thiosemicarbazide  97%

  • 6610-29-3

  • 130060-50G

  • 1,236.69CNY

  • Detail

6610-29-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Methylthiosemicarbazide

1.2 Other means of identification

Product number -
Other names 1-amino-3-methylthiourea

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6610-29-3 SDS

6610-29-3Relevant articles and documents

DNA cleavage, antimicrobial, spectroscopic and fluorescence studies of Co(II), Ni(II) and Cu(II) complexes with SNO donor coumarin Schiff bases

Patil, Sangamesh A.,Naik, Vinod H.,Kulkarni, Ajaykumar D.,Badami, Prema S.

, p. 347 - 354 (2010)

A series of Co(II), Ni(II) and Cu(II) complexes of the type ML2 have been synthesized with Schiff bases derived from methylthiosemicarbazone and 5-formyl-6-hydroxy coumarin/8-formyl-7-Hydroxy-4-methylcoumarin. The complexes are insoluble in common organic solvents but soluble in DMF and DMSO. The measured molar conductance values in DMF indicate that, the complexes are non-electrolytes in nature. In view of analytical, spectral (IR, UV-vis, ESR, FAB-mass and fluorescence), magnetic and thermal studies, it has been concluded that, all the metal complexes possess octahedral geometry in which ligand is coordinated to metal ion through azomethine nitrogen, thione sulphur and phenolic oxygen atom via deprotonation. The redox behavior of the metal complexes was investigated by using cyclic voltammetry. The Schiff bases and their complexes have been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus and Cladosporium) by Minimum Inhibitory Concentration method. The DNA cleavage is studied by agarose gel electrophoresis method.

Preparation process of 4-methylthiosemicarbazide

-

Paragraph 0016; 0028-0045, (2020/06/16)

The invention relates to a preparation process of 4-methylthiosemicarbazide, and belongs to the technical field of pharmaceutical chemicals. The preparation method comprises the following steps: adding hydrazine hydrate into a reaction bottle, dropwise adding carbon disulfide at 20-25 DEG C for 2-3 hours, and keeping the temperature at 20-25 DEG C for 1-2 hours after dropwise adding is finished; controlling the temperature to be 25-30 DEG C, dropwise adding monomethylamine into the reaction bottle for 1-2 hours, introducing nitrogen at the temperature of 70-75 DEG C after dropwise adding is finished, performing refluxing for 1-2 hours, and blowing off hydrogen sulfide gas generated by the reaction; and performing cooling to 0-5 DEG C, performing filtering to obtain an MTSC wet product, carrying out vacuum drying at 55 DEG C for 3 hours, performing heating to 70 DEG C, carrying out vacuum drying for 2-3 hours, and controlling the moisture content to be less than 0.1% to obtain white crystal powder 4-methylthiosemicarbazide. The preparation process is scientific and reasonable in design, wide in raw material source, low in cost, simple in step, green and pollution-free, improves theproduction efficiency, and is beneficial to industrial production.

Synthesis and characterization of a new series of thiadiazole derivatives as potential anticancer agents

?evik, Ulviye Acar,Osmaniye, Derya,Levent, Serkan,Sa?lik, Begüm Nurpelin,?avu?o?lu, Betül Kaya,?zkay, Yusuf,Kaplancikl, Zafer Aslm

, p. 6 - 13 (2020/03/30)

Cancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs are major problems in chemotherapy. Nowadays the aim of many medical research projects is to discover new safer and more effective anticancer agents. 1,3,4-Thiadiazole compounds are important fragments in medicinal chemistry because of their wide range of biological activities, including anticancer activities. The aim of this study was to determine the capacity of newly synthesized 1,3,4-thiadiazole compounds as chemotherapeutic agents. The structures of the obtained compounds were elucidated using 1H-NMR, 13C-NMR and mass spectrometry. Although the thiadiazole derivatives did not prove to be significantly cytotoxic to the tumour tissue cultures, compound 4i showed activity against the C6 rat brain cancer cell line (IC50 0.097 mM) at the tested concentrations.

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