66203-94-9

Basic information

• Product Name: murocainide
• Synonyms: murocainide;MD 750819;1-[4,7-Dimethoxy-6-(2-piperidinoethoxy)benzofuran-5-yl]-3-methylurea
• CAS NO: 66203-94-9
• Molecular Formula: C₁₉H₂₇N₃O₅
• Molecular Weight: 377.4348
• EINECS: 266-234-2
• Mol File: 66203-94-9.mol

Chemical Properties

• Boiling Point: 516.6°Cat760mmHg
• Flash Point: 266.2°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 8.84E-11mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: murocainide(CAS DataBase Reference)
• NIST Chemistry Reference: murocainide(66203-94-9)
• EPA Substance Registry System: murocainide(66203-94-9)

Safety Data

• Hazardous Substances Data: 66203-94-9(Hazardous Substances Data)

Usage

Uses

Used in Cardiology:
Murocainide is used as an antiarrhythmic agent for stabilizing abnormal heart rhythms. It is particularly effective in treating arrhythmias such as atrial fibrillation and ventricular tachycardia, providing a promising therapeutic option for patients suffering from irregular heartbeats.
Used in Pharmaceutical Industry:
Murocainide is used as a key component in the development of medications aimed at managing and treating cardiac arrhythmias. Its ability to block sodium channels in the heart muscle makes it a valuable asset in the creation of drugs that can effectively control irregular heartbeats without causing harm to the heart's normal functioning.
Further research is necessary to explore the full potential of murocainide in clinical practice, ensuring its safety and efficacy for patients with various types of arrhythmias.

InChI:InChI=1/C19H27N3O5/c1-20-19(23)21-14-15(24-2)13-7-11-26-16(13)18(25-3)17(14)27-12-10-22-8-5-4-6-9-22/h7,11H,4-6,8-10,12H2,1-3H3,(H2,20,21,23)

Upstream product

• 52631-80-8 5-amino-4,7-dimethoxy-6-benzofuranol 
• 1932-03-2 2-(piperidin-4-yl)ethyl chloride 
• 66203-89-2 N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)-N'-methylurea 
• 52631-78-4 1-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)ethanone oxime 
• 484-51-5 5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran 
• 52631-79-5 N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)acetamide 

Relevant articles and documents

Synthesis and Antiarrhythmic Activity of New Benzofuran Derivatives

Various 5-aminobenzofuran derivatives were prepared from khellin and screened intravenously in the dog for their potential antiarrhythmic activity against ouabain-induced ventricular arrhythmia and in the Harris test.From systematic structural variations it was found that two methoxy groups in positions 4 and 7 on the benzofuran ring, a tertiary aminoethoxy side chain in position 6, and a N-methylurea group in position 5 led to the most active compounds.These were then tested orally in the Harris test in the dog.The two long-acting derivativesN--N'-methylurea (8j) and N--N'-methylurea (8m) showed advantages when compared to quinidine and diisopyramide and have been selected for further studies.