66444-26-6Relevant articles and documents
Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin
Lipkowski, Andrzej W.,Misicka, Aleksandra,Davis, Peg,Stropova, Dagmar,Janders, Jacqueline,Lachwa, Magdalena,Porreca, Frank,Yamamura, Henry I.,Hruby, Victor J.
, p. 2763 - 2766 (2007/10/03)
The synthesis and biological activity of two fragments of the very potent opioid peptide biphalin, showed that Tyr-D-Ala-Gly-Phe-NH-NH-Phe is the minimal fragment necessary to express equal affinities and the same biological activity profile as the paren
Synthesis and pharmacological study of some enkephalin analogs in relation to the plurality of opiate receptors
Audigier,Mazarguil,Gout,Cros
, p. 173 - 177 (2007/10/02)
We have synthesized a series of enkephalin analogs and measured their affinity for each type of 'opiate' receptor, the μ receptor and the δ receptor. Furthermore, we have determined their respective antinociceptive activity after intracerebroventricular i