66893-75-2Relevant articles and documents
Fragment-oriented synthesis: β-elaboration of cyclic amine fragments using enecarbamates as platform intermediates
Trindade, Alexandre F.,Faulkner, Emily L.,Leach, Andrew G.,Nelson, Adam,Marsden, Stephen P.
supporting information, p. 8802 - 8805 (2020/08/17)
A strategy for the β-sp3 functionalisation of cyclic amines is described. Regioselective conversion of protected amines to enecarbamates is achieved through electrochemical oxidation; these intermediates can be derivatised by functionalised alkyl halides under photoredox catalysis. The potential of the methods is highlighted by direct growth of a DCP2B-binding fragment. This journal is
Diastereoselective synthesis of 3-fluoro-2-substituted piperidines and pyrrolidines
Gichuhi, Paul N.,Kuriyama, Masami,Onomura, Osamu
, p. 331 - 346 (2014/01/17)
A facile procedure for synthesis of trans-3-fluoro-2-substituted piperidines by utilizing electrophilic fluorination of cyclic enamines and Lewis acid mediated nucleophilic substitution has been developed. Also, optically active trans-2-allyl-3-fluorinate
Stereoselective synthesis of 3-deoxy-piperidine iminosugars from l-lysine
Moriyama, Noriaki,Matsumura, Yoshihiro,Kuriyama, Masami,Onomura, Osamu
scheme or table, p. 2677 - 2687 (2010/04/29)
A new method using electrochemical oxidation and/or OsO4 oxidation has been used for the stereoselective synthesis of 2,3,6-trihydroxylated (5S)-piperidine derivatives. The electrochemical method was successively used for the conversion of N-pr