6729-79-9Relevant articles and documents
A facile approach to bis(Isoxazoles), promising ligands of the ampa receptor
Averina, Elena B.,Grigoriev, Vladimir V.,Grishin, Yuri K.,Karlov, Dmitry S.,Kuznetsova, Tamara S.,Palyulin, Vladimir A.,Radchenko, Eugene V.,Rybakov, Victor B.,Sadovnikov, Kirill S.,Sedenkova, Kseniya N.,Vasilenko, Dmitry A.,Zamoyski, Vladimir L.
, (2021/11/01)
A convenient synthetic approach to novel functionalized bis(isoxazoles), the promising bivalent ligands of the AMPA receptor, was elaborated. It was based on the heterocyclization reactions of readily available electrophilic alkenes with the tetranitromethane-triethylamine complex. The structural diversity of the synthesized compounds was demonstrated. In the electrophysi-ological experiments using the patch clamp technique on Purkinje neurons, the compound 1,4-phenylenedi(methylene)bis(5-aminoisoxazole-3-carboxylate) was shown to be highly potent positive modulator of the AMPA receptor, potentiating kainate-induced currents up to 70% at 10?11 M.
Synthesis and characterization of triptycene type cross-linker and its use in photoinduced curing applications
Ates, Sahin,Aydogan, Binnur,Torun, Lokman,Yagci, Yusuf
scheme or table, p. 825 - 831 (2011/02/25)
A novel triptycene type diacrylate cross-linker, triptycene hydroquinone diacrylate (THDA) was synthesized from the reaction of triptycene hydroquinone with acryloyl chloride and characterized. The photocuring behaviour and the reaction kinetics of the synthesized cross-linker were investigated by means of photo-differential scanning calorimetry (photo-DSC) experiments. Formulations containing monofunctional (meth)acrylate monomers, namely glycidyl methacrylate (GMA), 2-hydroxyethyl acrylate (HEA), 2-hydroxyethyl methacrylate (HEMA), and 2-ethylhexyl methacrylate (EHMA), cross-linker, THDA and 2,2-dimethoxy-2-phenylacetophenone (DMPA) as a photoinitiator were irradiated. A?conventional cross-linker without triptycene unit such as hydroquinone diacrylate (HDA) was used under the same conditions for comparison. The effects of the structure of the monofunctional monomer and triptycene moiety on the photopolymerization kinetics were evaluated and discussed.
Biodegradable neuromuscular blocking agents. Part V. α,ω-bisquaternary polyalkylene phenolic esters
Stenlake,Waigh,Dewar,et al.
, p. 273 - 276 (2007/10/02)
A small group of α,ω-bisquaternary polyalkylene esters of quinol, catechol, and pyrogallol have been synthesised, and tested as potential biodegradable neuromuscular blocking agents. Three of the compounds were virtually inactive and the remainder of low potency compared to that of tubocuranine. Duration of action and vagal blockade have also been recorded.