6831-91-0

Basic information

• Product Name: 5-METHYL-1-PHENYL-1H-PYRAZOLE
• Synonyms: 5-METHYL-1-PHENYL-1H-PYRAZOLE;BUTTPARK 154\50-81;1-Phenyl-5-methylpyrazole;3-Methyl-2-phenylpyrazole;5-Methyl-1-phenylpyrazole;Pyrazole, 5-methyl-1-phenyl-
• CAS NO: 6831-91-0
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.2
• Product Categories: pharmacetical
• Mol File: 6831-91-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 263.5℃ (140 Torr)
• Flash Point: 108 °C
• Appearance: /
• Density: 1.1192 (rough estimate)
• Vapor Pressure: 0.0268mmHg at 25°C
• Refractive Index: 1.6392 (estimate)
• CAS DataBase Reference: 5-METHYL-1-PHENYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHYL-1-PHENYL-1H-PYRAZOLE(6831-91-0)
• EPA Substance Registry System: 5-METHYL-1-PHENYL-1H-PYRAZOLE(6831-91-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 6831-91-0(Hazardous Substances Data)

Usage

General Description

5-METHYL-1-PHENYL-1H-PYRAZOLE is a chemical compound with the molecular formula C10H10N2. It belongs to the class of organic compounds known as pyrazoles, which are aromatic heterocyclic compounds containing a five-membered ring with two nitrogen atoms and three carbon atoms. 5-METHYL-1-PHENYL-1H-PYRAZOLE is a derivative of pyrazole, which is commonly used as a building block in organic synthesis and pharmaceutical research. Its structure and properties make it a versatile and valuable intermediate in the production of various specialty chemicals and pharmaceuticals. Additionally, it has been studied for its potential biological and pharmacological activities, such as its role as a potential anti-inflammatory or anti-cancer agent.

InChI:InChI=1/C10H10N2/c1-9-7-8-11-12(9)10-5-3-2-4-6-10/h2-8H,1H3

Upstream product

• 89193-19-1 4-hydroxy-5-methyl-1-phenylpyrazole 
• 14575-62-3 5-methyl-1-phenyl-1,2-dihydro-pyrazol-3-one 
• 28022-64-2 2,5-dimethyl-1-phenyl-1H-pyrazole-3-thione 
• 91138-00-0 5-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 10199-57-2 5-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid 
• 26565-72-0 2,5-dimethyl-1-phenyl-1H-pyrazolium iodide 
• 625-34-3 3-oxobutyraldehyde 
• 64-19-7 acetic acid 
• 100-63-0 phenylhydrazine 
• 6123-63-3 4-acetyl-5-methyl-1-phenylpyrazole 
• 107-21-1 ethylene glycol 
• 1126-00-7 1-phenylpyrazole 
• 74-88-4 methyl iodide 
• 77936-92-6 5-methyl-1-phenyl-1H-pyrazole-3,4-dicarboxylic acid 

Downstream Products

• 26565-72-0 2,5-dimethyl-1-phenyl-1H-pyrazolium iodide 
• 50877-44-6 1-Phenyl-4-brom-5-methylpyrazol 
• 1133-77-3 2-phenyl-2H-pyrazole-3-carboxylic acid 
• 1453-58-3 3-Methylpyrazole 
• 103753-92-0 5-methyl-4-nitro-1-(4-nitro-phenyl)-1H-pyrazole 
• 1360469-07-3 2,5-dimethyl-1-phenylpyrazol-2-ium-4-sulfonate 
• 1353503-21-5 5-methyl-1-phenylpyrazole-4-sulfonic acid 
• 1360469-10-8 2-ethyl-5-methyl-1-phenylpyrazol-2-ium-4-sulfonate 
• 103038-19-3 4-(5-methyl-4-nitro-pyrazol-1-yl)-aniline 
• 150587-22-7 5-methyl-1-phenyl-1H-imidazole 

Relevant articles and documents

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Copper-catalyzed arylation of nitrogen heterocycles from anilines under ligand-free conditions

The arylation of pyrazole and derivatives can be achieved by coupling arenediazonium species (formed in situ from anilines) by using a catalytic system that employs low-toxicity and inexpensive copper metal under very mild and ligand-free conditions (T = 20 ° C). From other nitrogen heterocycles, the presence of an additive (NBu4I) significantly improves the efficiency of the catalytic system. These results represent the first examples of C-N bond formation from arenediazonium species.

Regioselective synthesis of 1-aryl-3,4-substituted/annulated-5-(methylthio) pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/annulated pyrazoles

Highly efficient and regioselective synthesis of 1-aryl-3,4-substituted/ annulated-5-(methylthio)-pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/ annulated pyrazoles has been reported via cyclocondensation of arylhydrazines with either α-oxoketene dithioacetals or β-oxodithioesters.