68497-63-2

Basic information

• Product Name: methyl-2-oxo-4-phenylpyrrolidine-1-acetate
• Synonyms: methyl-2-oxo-4-phenylpyrrolidine-1-acetate
• CAS NO: 68497-63-2
• Molecular Weight: 233.267
• Mol File: 68497-63-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl-2-oxo-4-phenylpyrrolidine-1-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl-2-oxo-4-phenylpyrrolidine-1-acetate(68497-63-2)
• EPA Substance Registry System: methyl-2-oxo-4-phenylpyrrolidine-1-acetate(68497-63-2)

Safety Data

• Hazardous Substances Data: 68497-63-2(Hazardous Substances Data)

Upstream product

• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 1198-97-6 4-phenylpyrrolidin-2-one 
• 106869-48-1 4-phenyl-1-(trimethylsilyl)-2-pyrrolidinone 
• 96-32-2 bromoacetic acid methyl ester 
• 96-34-4 methyl chloroacetate 
• 3060-41-1 (±)-3-carboxy-2-phenylpropan-1-aminium chloride 

Downstream Products

• 68497-64-3 N-[3-[bis(1-methylethyl)amino]propyl]-2-oxo-4-phenyl-1-pyrrolidineacetamide 
• 88981-74-2 cis-N-[2-(2,6-dimethyl-1-piperidinyl)ethyl]-2-oxo-4-phenyl-1-pyrrolidineacetamide 
• 68644-48-4 N-[2-(diethylamino)ethyl]-2-oxo-4-phenyl-1-pyrrolidineacetamide 
• 77472-70-9 (RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide 
• 132351-24-7 2-(2-oxo-4-phenylpyrrolidinomethyl)benmzimidazole 

Relevant articles and documents

Method for preparing phenyl piracetam

The invention discloses a method for preparing phenyl piracetam, and belongs to the field of compound preparing. The method includes the following steps that alkali, cinnamic acid alkyl ester and nitromethane are subjected to an addition reaction to obtain 4-nitryl-3-phenylbutyric acid alkyl ester; after nitryl of the 4-nitryl-3-phenylbutyric acid alkyl ester is reduced with a reducing agent, the reduced nitryl and carbonyl are cyclized, and 4-phenyl-2-pyrrolidone is obtained; alkali, haloacetic acid alkyl ester and the 4-phenyl-2-pyrrolidone are subjected to an alkylation reaction to obtain 4-phenyl-2-pyrrolidone-1-acetic acid alkyl ester; the 4-phenyl-2-pyrrolidone-1-acetic acid alkyl ester and ammonia gas are reacted to obtain the phenyl piracetam. The method has the advantages of being short in reaction step, high in atom utilization, more environmentally friendly, safe in operation, high in reaction yield and purity, beneficial for achieving industrialization an the like.

SIMPLE METHODS FOR THE N-ALKYLATION OF LACTAMS

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Pyrrolidineacetic acid esters

Lower alkyl 2-oxo-4-phenyl-1-pyrrolidineacetic acid esters which are useful as pharmacological agents, especially cognition activators, are disclosed. They can be produced by reacting 4-phenyl-2-pyrrolidinone with a lower alkyl haloacetate in the presence of a strong base.