68592-18-7

Basic information

• Product Name: 1-methoxy-4-(2-methoxy-5-prop-2-enyl-phenyl)-2-prop-2-enyl-benzene
• CAS NO: 68592-18-7
• Molecular Formula: C₂₀H₂₂O₂
• Molecular Weight: 294.393
• Mol File: 68592-18-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 377.7°Cat760mmHg
• Flash Point: 130.5°C
• Density: 1.009g/cm³
• CAS DataBase Reference: 1-methoxy-4-(2-methoxy-5-prop-2-enyl-phenyl)-2-prop-2-enyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methoxy-4-(2-methoxy-5-prop-2-enyl-phenyl)-2-prop-2-enyl-benzene(68592-18-7)
• EPA Substance Registry System: 1-methoxy-4-(2-methoxy-5-prop-2-enyl-phenyl)-2-prop-2-enyl-benzene(68592-18-7)

Safety Data

• Hazardous Substances Data: 68592-18-7(Hazardous Substances Data)

Usage

Naturally occurring chemical compound

Eugenol is a naturally occurring chemical compound found in various plants such as clove, cinnamon, and basil.

Flavoring agent

It is commonly used as a flavoring agent in food and beverages due to its pleasant aroma and taste.

Antiseptic properties

Eugenol possesses antiseptic properties, making it a popular ingredient in dental and oral care products.

Antioxidant properties

Eugenol also has antioxidant properties, which can help prevent the oxidation of cells and tissues in the body.

Anti-inflammatory properties

Eugenol has anti-inflammatory properties, which can help reduce inflammation and swelling in the body.

Analgesic properties

Eugenol is used in traditional medicine for its analgesic properties, which can help relieve pain.

Antifungal properties

Eugenol has antifungal properties, which can help prevent the growth of fungi in the body.

Potential anti-cancer properties

Eugenol has been studied for its potential anti-cancer properties and is used as a base for the synthesis of other pharmaceuticals and perfumes.

Upstream product

• 35354-74-6 Honokiol 
• 74-88-4 methyl iodide 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 35354-74-6 Honokiol 

Relevant articles and documents

Synthesis and in vitro antitumor evaluation of honokiol derivatives

Honokiol is a natural bioactive neolignan and has been widely researched and structural modified as an anticancer agent. In this paper, 18 honokiol derivatives were synthesized and investigated for their antitumor activity. Among these, the promising compound 5a exhibited much higher anti-proliferative activity with IC50 value of 10.41 μM. Transwell assays showed that 5a could significantly inhibit the invasion and migration of I-10 cells at 2.5 μM, which was further confirmed by the western blotting experiments with down-regulation of the HIF-1α and its associated downstream proteins MMP-2 and MMP-9. Overall, these results provided useful suggestion for further structural optimization of honokiol derivatives.

Structural modification of honokiol, a biphenyl occurring in magnolia officinalis: The evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship

Honokiol, widely known as an antitumor agent, has been used as an antiangiogenesis drug lead. In this paper, 47 honokiol analogues and derivatives were investigated for their antiangiogenic activity by application of the transgenic zebrafish screening model, antiproliferative and cytotoxic activity against HUVECs, and three tumor cell lines by MTT assay. 3′,5-Diallyl-2, 4′-dihydroxy-[1,1′-biphen-yl]-3,5′-dicarbaldehyde (8c) was found to suppress the newly grown segmental vessels from the dorsal aorta of zebrafish and prevent inappropriate vascularization as well as exhibit more potent inhibitory effects on the proliferation of HUVECs, A549, HepG2, and LL/2 cells (IC50 = 15.1, 30.2, 10.7, and 21.7 μM, respectively) than honokiol (IC50 = 52.6, 35.0, 16.5, and 65.4 μM, respectively). Analogue 8c also effectively inhibited the migration and capillary-like tube formation of HUVECs in vitro. The antiangiogenic effect and antiproliferative activity of these structurally modified honokiol analogues and derivatives have led to the establishment of a structure-activity relationship.