Welcome to LookChem.com Sign In|Join Free

CAS

  • or

68592-19-8

Post Buying Request

68592-19-8 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

68592-19-8 Usage

General Description

[1,1'-Biphenyl]-4-ol, 2'-methoxy-3,5'-di-2-propenyl- is a chemical compound with a complex and specific structure. It belongs to the class of biphenyl compounds and is characterized by the presence of a hydroxyl group and two propenyl groups attached to different carbon atoms of the biphenyl ring. The methoxy group is also present at the 2' position of the biphenyl ring. [1,1'-Biphenyl]-4-ol, 2'-methoxy-3,5'-di-2-propenyl- has been studied for its potential biological and pharmacological activities, including its antioxidant and antimicrobial properties. It may also have potential applications in the fields of medicine and material science. The specific structure and functional groups present in [1,1'-Biphenyl]-4-ol, 2'-methoxy-3,5'-di-2-propenyl- make it an interesting compound for further research and potential industrial applications.

Check Digit Verification of cas no

The CAS Registry Mumber 68592-19-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,5,9 and 2 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 68592-19:
(7*6)+(6*8)+(5*5)+(4*9)+(3*2)+(2*1)+(1*9)=168
168 % 10 = 8
So 68592-19-8 is a valid CAS Registry Number.

68592-19-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(2-methoxy-5-prop-2-enylphenyl)-2-prop-2-enylphenol

1.2 Other means of identification

Product number -
Other names 2-O-methoxy-hinokiol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:68592-19-8 SDS

68592-19-8Downstream Products

68592-19-8Relevant articles and documents

Synthesis and in vitro antitumor evaluation of honokiol derivatives

Zhu, Meilin,Li, Bohan,Ma, Hui,Huang, Xuenan,Wang, Haotian,Dai, Yiqun,Li, Yu,Li, Hong-Mei,Wu, Cheng-Zhu

supporting information, (2019/12/25)

Honokiol is a natural bioactive neolignan and has been widely researched and structural modified as an anticancer agent. In this paper, 18 honokiol derivatives were synthesized and investigated for their antitumor activity. Among these, the promising compound 5a exhibited much higher anti-proliferative activity with IC50 value of 10.41 μM. Transwell assays showed that 5a could significantly inhibit the invasion and migration of I-10 cells at 2.5 μM, which was further confirmed by the western blotting experiments with down-regulation of the HIF-1α and its associated downstream proteins MMP-2 and MMP-9. Overall, these results provided useful suggestion for further structural optimization of honokiol derivatives.

Nitrogenated honokiol derivatives allosterically modulate GABAA receptors and act as strong partial agonists

Bernaskova, Marketa,Schoeffmann, Angela,Schuehly, Wolfgang,Hufner, Antje,Baburin, Igor,Hering, Steffen

, p. 6757 - 6762 (2015/10/20)

In traditional Asian medicinal systems, preparations of the root and stem bark of Magnolia species are widely used to treat anxiety and other nervous disturbances. The biphenyl-type neolignan honokiol together with its isomer magnolol are the main constituents of Magnolia bark extracts. We have previously identified a nitrogen-containing honokiol derivative (3-acetylamino-4′-O-methylhonokiol, AMH) as a high efficient modulator of GABAA receptors. Here we further elucidate the structure-activity relation of a series of nitrogenated biphenyl-neolignan derivatives by analysing allosteric modulation and agonistic effects on α1β2γ2S GABAA receptors. The strongest IGABA enhancement was induced by compound 5 (3-acetamido-4′-ethoxy-3′,5-dipropylbiphenyl-2-ol, Emax: 123.4 ± 9.4% of IGABA-max) and 6 (5′-amino-2-ethoxy-3′,5-dipropylbiphenyl-4′-ol, Emax: 117.7 ± 13.5% of IGABA-max). Compound 5 displayed, however, a significantly higher potency (EC50 = 1.8 ± 1.1 μM) than compound 6 (EC50 = 20.4 ± 4.3 μM). Honokiol, AMH and four of the derivatives induced significant inward currents in the absence of GABA. Strong partial agonists were honokiol (inducing 78 ± 6% of IGABA-max), AMH (63 ± 6%), 5′-amino-2-O-methylhonokiol (1) (59 ± 1%) and 2-methoxy-5′-nitro-3′,5-dipropylbiphenyl-4′-ol (3) (52 ± 1%). 3-N-Acetylamino-4′-ethoxy-3′,5-dipropyl-biphenyl-4′-ol (5) and 3-amino-4′-ethoxy-3′,5-dipropyl-biphenyl-4′-ol (7) were less efficacious but even more potent (5: EC50 = 6.9 ± 1.0 μM; 7: EC50 = 33.2 ± 5.1 μM) than the full agonist GABA.

Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan

Esumi, Tomoyuki,Makado, Gouki,Zhai, Haifeng,Shimizu, Yasuhiro,Mitsumoto, Yasuhide,Fukuyama, Yoshiyasu

, p. 2621 - 2625 (2007/10/03)

Honokiol, a biphenyl-type neolignan, which shows the remarkable neurotrophic effect in primary cultured rat cortical neurons, has been effectively synthesized in 21% yield over 14 steps starting from 5-bromosalicylic acid and p-hydroxybenzoic acid by utilizing Pd-catalyzed Suzuki-Miyaura coupling reaction as a key step. Additionally, the structure-activity relationship between neurite outgrowth-promoting activity and its O-methylated and/or its hydrogenated analogues was examined in the primary cultures of fetal rat cortical neurons, suggesting that 5-allyl and 4′-hydroxyl groups are essential for affecting the neurotrophic activity of honokiol.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 68592-19-8