6941-70-4

Basic information

• Product Name: 6-bromo-1,3-benzodioxol-5-ol
• CAS NO: 6941-70-4
• Molecular Formula: C₇H₅BrO₃
• Molecular Weight: 217.0168
• Mol File: 6941-70-4.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 283.4°C at 760 mmHg
• Flash Point: 125.2°C
• Density: 1.883g/cm³
• Vapor Pressure: 0.00185mmHg at 25°C
• Refractive Index: 1.649
• CAS DataBase Reference: 6-bromo-1,3-benzodioxol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-1,3-benzodioxol-5-ol(6941-70-4)
• EPA Substance Registry System: 6-bromo-1,3-benzodioxol-5-ol(6941-70-4)

Safety Data

• Hazardous Substances Data: 6941-70-4(Hazardous Substances Data)

Usage

General Description

6-bromo-1,3-benzodioxol-5-ol, also known as 5-Bromo-1,3-benzodioxole-6-ol, is an organic compound with the molecular formula C8H7BrO3. It is a derivative of benzodioxole, a chemical compound commonly found in natural sources such as plants and fungi. 6-bromo-1,3-benzodioxol-5-ol is known for its potential applications in pharmaceutical research, particularly in the development of new drugs and medications. It possesses several important functional groups, including a bromine atom and a hydroxyl group, which contribute to its reactivity and biological activity. Due to its unique structure and properties, this compound is of interest to scientists and researchers in the fields of chemistry, pharmacology, and drug discovery.

Upstream product

• 533-31-3 Sesamol 

Downstream Products

• 10022-35-2 1-bromo-2-methoxy-4,5-methylenedioxybenzene 
• 5460-53-7 1-acetoxy-2-bromo-4,5-methylenedioxybenzene 
• 628328-75-6 methyl 6-[3-(1-hydroxy-6,7-methylenedioxynaphthyl)]-2,3-dimethoxybenzoate 
• 2035-15-6 (+/-)-3-hydroxy-8,9-methylenedioxyprerocarpan 
• 76240-26-1 (+/-)-3-benzyloxy-8,9-methylenedioxyprerocarpan 
• 1160293-80-0 3-bromo-5,6-methylenedioxy-2-naphthyl p-toluenesulfonate 
• 673477-44-6 6-(2'-(2'',4''-diacetoxyphenyl)ethynyl)-1-methoxy-3,4-methylenedioxybenzene 
• 950852-66-1 benzyl [(S)-1-benzyl-2-(6-bromobenzo[1,3]dioxol-5-yloxy)ethyl]amine 
• 6316-28-5 5-bromo-6-[1]naphthoyloxy-benzo[1,3]dioxole 
• 6936-58-9 5-benzoyloxy-6-bromo-benzo[1,3]dioxole 
• 1612146-87-8 methyl 6-[4-(4-methoxybenzyloxy)-2-(methoxymethoxy)benzyloxy]benzo[d][1,3]dioxole-5-carboxylate 
• 1612146-84-5 methyl 6-[4-methoxy-2-(methoxymethoxy)benzyloxy]benzo[d][1,3]-dioxole-5-carboxylate 

Relevant articles and documents

Synthesis and pharmacological activities of some sesquiterpene quinones and hydroquinones

Synthesis of protected siphonodictyal C was achieved via drim-7-en-11-al. Some sesquiterpene quinones and hydroquinones were tested for their pharmacological activities in assays in search of antiproliferative, cytotoxic, antiphlogistic, antirheumatic and anti-inflammatory drugs. Wiedendiol B is a ten times stronger cyclooxygenase-2 inhibitor than the reference compound indomethacine. Cyclooxygenase-2 inhibitors are drugs with antiphlogistic and antirheumatic activity.

Expedient Pd-Catalyzed α-Arylation towards Dibenzoxepinones: Pivotal Manske's Ketone for the Formal Synthesis of Cularine Alkaloids

The general synthesis of diversely substituted dibenzoxepinones by a combined Pd-catalyzed α-arylation and SNAr strategy is reported and applied to the synthesis of Manske's ketone, a key intermediate en route to the total synthesis of cularine alkaloids. In the course of this work, an unanticipated ring contraction reaction to a xanthone was observed and serves as a caveat for the conditions of the widely used α-arylation reaction.

A Three-Phase Four-Component Coupling Reaction: Selective Synthesis of o-Chloro Benzoates by KCl, Arynes, CO2, and Chloroalkanes

A transition-metal-free three-phase four-component coupling reaction (3P-4CR) involving KCl, arynes, chloroalkanes and CO2 has been reported for the first time, enabling the incorporation of both chloro and CO2 into an aryne simultaneously. The reactions for the synthesis of different types of o-chloro benzoates can be selectively modulated by the chloroalkane utilized. The corresponding products can be alternatively transformed for postsynthetic functionalizations conveniently.