6946-46-9Relevant articles and documents
CATIONIC LIPID
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Paragraph 0058; 0060, (2017/11/17)
The present invention provides a cationic lipid which can be utilized for nucleic acid delivery into the cytoplasm. The cationic lipid of the present invention is, for example, a compound represented by the following Formula (1) or a pharmaceutically acceptable salt thereof.
Synthesis and anti-cancer activity of C-ring-functionalized prodigiosin analogues
Regourd, Jasmine,Ali, Adeeb Al-Sheikh,Thompson, Alison
, p. 1528 - 1536 (2008/02/02)
Prodigiosin is the parent member of the 4-methoxypyrrolyldipyrromethene family of natural products and is known for its anti-cancer activity. A new series of analogues was synthesized, incorporating pendent functional esters and β-carbonyl substituents on the C-ring. The β-carbonyl group allowed for the facile isolation of the prodigiosenes, and the pendent esters allow for further derivatization. The novel prodigiosenes generally retain the anti-cancer activity of prodigiosin in 60 human cell lines derived from nine cancer cell types, with neither the conjugated /3-carbonyl group, as either ketone or ester, nor the pendent ester significantly reducing the anti-cancer activity of the core skeleton.
SYNTHESE BIOLOGISCH AKTIVER UNGESAETTIGTER AMIDE
Bohlmann, Ferdinand,Ganzer, Michael,Krueger, Martin,Nordhoff, Erhard
, p. 123 - 128 (2007/10/02)
The synthesis of seven naturally occurring unsaturated amides is described.