6949-77-5

Basic information

• Product Name: 1-AMINO-1-CYCLOHEPTANECARBOXYLIC ACID
• Synonyms: 1-amino-cycloheptanecarboxylicaci;1-AMINO-1-CYCLOHEPTANECARBOXYLIC ACID;1-AMINO-CYCLOHEPTANECARBOXYLIC ACID;1-Aminocycloheptane-1-carboxylic acid;cycloheptanecarboxylic acid, 1-amino-;1-AMino-1-cycloheptanecarboxylic aicd;1-ammonio-1-cycloheptanecarboxylate;1-ammoniocycloheptane-1-carboxylate
• CAS NO: 6949-77-5
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.21
• Product Categories: pharmacetical
• Mol File: 6949-77-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 320 °C (decomp)(Solv: water (7732-18-5))
• Boiling Point: 288.9 °C at 760 mmHg
• Flash Point: 128.5 °C
• Appearance: /
• Density: 1.103 g/cm³
• Vapor Pressure: 0.000573mmHg at 25°C
• Refractive Index: 1.499
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: pK1: 2.59(+1);pK2: 10.46(0) (25°C)
• CAS DataBase Reference: 1-AMINO-1-CYCLOHEPTANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-AMINO-1-CYCLOHEPTANECARBOXYLIC ACID(6949-77-5)
• EPA Substance Registry System: 1-AMINO-1-CYCLOHEPTANECARBOXYLIC ACID(6949-77-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 6949-77-5(Hazardous Substances Data)

Usage

Uses

1-?Aminocycloheptanecar?boxylic Acid is used in the synthesis of chlamydocin-hydroxamic acid analogs with histone deacetylase inhibitory activities. It is also used to prepare imidazobioxazolium triflates as precursors for sterically hindered and electron-donating N-heterocyclic carbene ligands.

InChI:InChI=1/C8H15NO2/c9-8(7(10)11)5-3-1-2-4-6-8/h1-6,9H2,(H,10,11)

Upstream product

• 773837-37-9 sodium cyanide 
• 502-42-1 cycloheptanone 
• 123193-99-7 1-aminocycloheptanecarbonitrile 
• 707-16-4 1,3-diaza-spiro[4.6]undecane-2,4-dione 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 183429-63-2 C₉H₁₇NO₂ 
• 94460-89-6 1-(1,3-dioxoisoindolin-2-yl)cycloheptane-1-carboxylic acid 
• 92398-50-0 methyl 1-amino-cycloheptanecarboxylate hydrochloride 
• 1269074-85-2 3-(2-chloro-4-nitrophenyl)-1,3-diazaspiro[4.6]undecane-2,4-dione 
• 92398-64-6 N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-α-aminocycloheptanecarboxylic acid methyl ester 
• 814254-62-1 (1-aminocycloheptyl)methanol 
• 197794-44-8 1-Benzyloxycarbonylamino-cycloheptanecarboxylic acid 
• 188751-56-6 Fmoc-1-aminocycloheptane-1-carboxylic acid 
• 199330-56-8 1-(tert-butoxycarbonylamino) cycloheptanecarboxylic acid 
• 912771-18-7 1-(3-fluorobenzamido)cycloheptanecarboxylic acid 
• 7690-59-7 3-oxa-1-azaspiro[4.6]undecane-2,4-dione 

Relevant articles and documents

Remote Amino Acid Recognition Enables Effective Hydrogen Peroxide Activation at a Manganese Oxidation Catalyst

Precise delivery of a proton plays a key role in O2 activation at iron oxygenases, enabling the crucial O?O cleavage step that generates the oxidizing high-valent metal–oxo species. Such a proton is delivered by acidic residues that may either

Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

The exploration of innovative chemical space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biologically relevant metabolites and show attractive features, such as molecular compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available commercial reagents and robust chemical transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented.

Microwave-assisted synthesis of cycloalkanespirohydantoins and piperidinespirohydantoins as precursors of restricted α-amino acids

Cycloalkanespirohydantoins 3 and piperidinespirohydantoins 4 were synthesized from cycloalkanones 9 and piperidones 10 under microwave-assisted conditions. Results are compared with those obtained under thermal conditions. Cycloalkanespirohydantoins 3 were N-protected with Boc group and hydrolyzed under basic conditions to obtain five, six and seven-membered ring restricted α-amino acids 12 in very good overall yields (76-94%). ARKAT USA, Inc.