6968-72-5

Basic information

• Product Name: 3-PYRIDINEMETHANOL N-OXIDE
• Synonyms: 3-pyridylmethanol N-oxide;mepiroxol;pyridine-3-methanol N-oxide;3-(Hydroxymethyl)pyridine 1-oxide;3-Pyridinemethanol 1-oxide;(1-oxidopyridin-1-ium-3-yl)methanol;3-PYRIDYLCARBINOL N-OXIDE;3-PYRIDINEMETHANOL N-OXIDE
• CAS NO: 6968-72-5
• Molecular Formula: C₆H₇NO₂
• Molecular Weight: 125.13
• EINECS: 230-187-6
• Mol File: 6968-72-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 87-89 °C(lit.)
• Boiling Point: 391.3°C at 760 mmHg
• Flash Point: 190.5°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 7.95E-07mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: 3-PYRIDINEMETHANOL N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PYRIDINEMETHANOL N-OXIDE(6968-72-5)
• EPA Substance Registry System: 3-PYRIDINEMETHANOL N-OXIDE(6968-72-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 6968-72-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 6968-72-5 differently. You can refer to the following data:
1. antihyperlipemic
2. 3-Pyridylcarbinol N-oxide was used to develop a series of urinary biomarkers to assess the metabolic activation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in humans.

InChI:InChI=1/C6H7NO2/c8-5-6-2-1-3-7(9)4-6/h1-4,8H,5H2

Upstream product

• 100-55-0 3-hydroxymethylpyridin 
• 75-57-0 tetramethlyammonium chloride 
• 82401-08-9 3-(chloromethyl)pyridine N-oxide 

Downstream Products

• 500-22-1 3-pyridinecarboxaldehyde 
• 100-55-0 3-hydroxymethylpyridin 
• 114951-34-7 3-Acetoxymethylpyridine-N-oxide 

Relevant articles and documents

Amino-polystyrene supported hexaethylene glycol-bridged ionic liquid as an efficient heterogeneous catalyst for water-mediated nucleophilic hydroxylation

We report a simple and eco-friendly method for producing an amino-polystyrene supported hexaethylene glycol-bridged ionic liquid (APS-HEGBIL) based on the copolymerization of amino-styrene with 1-vinyl imidazolium ionic liquid bearing hexaethylene glycol moieties, and its characterization by several analytical techniques. The resulting APS-HEGBIL catalyst was found to be remarkably efficient at catalyzing the selective nucleophilic hydroxylation of alkyl halides to produce the corresponding alcohols in water, which acted as a solvent and a nucleophilic hydroxide source. The catalyst was easily recycled and maintained its catalytic activity and stability after ten cycles with excellent yields. The main attributes of the catalyst were that it significantly enhanced the nucleophilicity of water during reactions and promoted the rapid conversions of polar and base-sensitive alkyl halide reactants to alcohols in excellent yields. The combination of ionic liquids and polymeric materials afforded quasi-homogeneous catalysts that were recycled by simple filtration and provided environmentally benign means for conducted catalytic procedures.

The Mechanism of the Reaction of Nicotinic Acid 1-Oxide with Acetic Anhydride

In order to elucidate the mechanism of the 2-acetylation in the reaction of nicotinic acid 1-oxide (2a) with boiling acetic anhydride, thermal reactions and reactions with hot acetic anhydride have been explored with 3-X-pyridine 1-oxides (2).The former reactions of 2d (X = CONHAc), 2f (X = CONMeAc), 2h (X = CH2OAc) and 2j result in recovery or decomposition.The latter reactions of 2c (X = CONH2), 2d, 2e (X = CONHMe), 2h and 2j bring about mainly deoxygenative α-acetoxylation, no 2-acetylation being noticed.However, the reaction of 2f with acetic anhydride affords 6,7-dihydro-6-methyl-7-methylene-5H-pyrrolopyridin-5-one 1-oxide (7) as an initial product, which further undergoes deoxygenative β-acetoxylation to give 7-acetoxy-7-acetoxymethyl-6,7-dihydro-6-methyl-5H-pyrrolopyridin-5-one (8) and 7-acetoxymethylene-6,7-dihydro-6-methyl-5H-pyrrolopyridin-5-one (9).On the basis of the results we propose a new electrophilic pathway for the 2-acetylation of 2a and 2f.Keywords - pyridine 1-oxide 3-substituted; nicotinic acid 1-oxide; nicotinamide 1-oxide N-acetyl-N-methyl; pyrrolopyridine; 2-acetylation; pyridone formation