6972-69-6

Basic information

• Product Name: N,N-DIMETHYLNICOTINAMIDE
• Synonyms: dimethylnicotinamide;N,N-DIMETHYLNICOTINAMIDE;3-Pyridinecarboxamide,N,N-dimethyl-(9CI);NICOTINAMIDE, N,N-DIMETHYL- (8CI);3-(Dimethylcarbamoyl)pyridine;N,N-Dimethylpyridine-3-carboxamide;3-Pyridinecarboxamide, N,N-dimethyl-;3-Pyridinecarboxylic acid,amide,N,N-dimethyl
• CAS NO: 6972-69-6
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• EINECS: 230-209-4
• Product Categories: AMIDE
• Mol File: 6972-69-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 44°C
• Boiling Point: 147 °C / 9mmHg
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: N,N-DIMETHYLNICOTINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYLNICOTINAMIDE(6972-69-6)
• EPA Substance Registry System: N,N-DIMETHYLNICOTINAMIDE(6972-69-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 6972-69-6(Hazardous Substances Data)

Usage

General Description

N,N-dimethylnicotinamide is a chemical compound that belongs to the class of nicotinamides, which are derivatives of niacin (vitamin B3). It is an amide of nicotinic acid and dimethylamine, and is commonly used as a precursor in the synthesis of pharmaceuticals and other organic compounds. N,N-dimethylnicotinamide has several potential pharmaceutical applications, including as an anti-inflammatory and anti-fibrotic agent. It is also being studied for its potential role in treating metabolic disorders and as a possible therapeutic agent for certain neurological conditions. Additionally, it has been investigated for its potential use in organic light-emitting diode (OLED) devices due to its electronic and optical properties.

Upstream product

• 626-55-1 3-Bromopyridine 
• 18503-89-4 N,N-dimethylformamide diisopropyl acetal 
• 68-12-2 N,N-dimethyl-formamide 
• 59-67-6 nicotinic acid 
• 79-44-7 N,N-Dimethylcarbamoyl chloride 
• 500-22-1 3-pyridinecarboxaldehyde 
• 124-40-3 dimethyl amine 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 506-59-2 N,N-dimethylammonium chloride 
• 373-68-2 tetramethylammonium fluoride 
• 98-92-0 nicotinamide 
• 677-22-5 tert-butylmagnesium chloride 
• 52943-21-2 2-chloropyridine-3-carboxylic acid N,N-dimethylamide 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 

Downstream Products

• 132778-92-8 1-(2,6-dichloro-benzyl)-3-dimethylcarbamoyl-pyridinium; bromide 
• 58287-38-0 3-dimethylcarbamoyl-1-methyl-pyridinium; iodide 
• 500-22-1 3-pyridinecarboxaldehyde 
• 5505-20-4 N,N-dimethyl-3-piperidinecarboxamide 
• 111991-09-4 nicosulfuron 
• 14548-44-8 3-(4-chlorobenzoyl)pyridine 
• 59547-43-2 1-benzyl-1,4-dihydro-pyridine-3-carboxylic acid dimethylamide 
• 100-54-9 pyridine-3-carbonitrile 
• 113944-88-0 1-(2,6-dichloro-benzyl)-1,4-dihydro-pyridine-3-carboxylic acid dimethylamide 
• 77924-13-1 N,N-Dimethyl-4-(pyridine-3-carbonyl)-nicotinamide 
• 59-26-7 N,N-diethylnicotinamide 
• 1402916-79-3 3-(dimethylcarbamoyl)-1-(((2-(4-isobutylphenyl)propanoyl)oxy)methyl)pyridin-1-ium iodide 
• 1402916-74-8 1-((((((1S,2R)-1-benzamido-3-(((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-diacetoxy-12-(benzoyloxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[l,2-b]oxet-9-yl)oxy)-3-oxo-1-phenylpropan-2-yl)oxy)carbonyl)oxy)methyl)-3-(dimethylcarbamoyl)pyridin-1-ium iodide iodomethyl 2-(4-isobutylphenyl)propanoate 
• 1402916-56-6 1-((((4-acetamidophenoxy)carbonyl)oxy)methyl)-3-(dimethylcarbamoyl)pyridin-1-ium iodide 

Relevant articles and documents

Palladium-Catalyzed Aminocarbonylation of Aryl Halides with N,N-Dialkylformamide Acetals

We developed a protocol for the palladium-catalyzed aminocarbonylation of aryl halides using less-toxic formamide acetals as bench-stable aminocarbonyl sources under neutral conditions. Various aryl (including heteroaryl) halides reacted with N,N-dialkylformamide acetals in the presence of a catalytic amount of tris(dibenzylideneacetone)dipalladium(0)-chloroform adduct and xantphos to give the corresponding aromatic carboxamides at 90–140 °C without any activating agents or bases in up to quantitative chemical yield. This protocol was applied to aryl bromides, aryl iodides, and trifluoromethanesulfonic acid, as well as to relatively less-reactive aryl chlorides. A wide range of functionalities on the aromatic ring of the substrates were tolerated under the aminocarbonylation conditions. The catalytic aminocarbonylation was used to prepare the insect repellent N,N-diethyl-3-methylbenzamide as well as a synthetic intermediate of the dihydrofolate reductase inhibitor triazinate.

POCl3 promoted metal-free synthesis of tertiary amides by coupling of carboxylic acids and N,N-disubstituted formamides

Herein we report a robust and synthetically useful catalyst-free amination methodology by the coupling of carboxylic acids and N-substituted formamides using POCl3 as a promoter. Versatile amides with a wide array of substituent groups were prepared within only 1 h in good to excellent yields. And even multi-substituted aromatic carboxylic acids could give the desired products with satisfactory results.

Method for synthesizing phosphorus-oxychloride-promoted amide compound

The invention relates to a method for synthesizing a phosphorus-oxychloride-promoted amide compound. The synthesizing method includes the steps that carboxylic acid serves as one reactant, another reactant (N,N-dialkyl methanamide) serves as a solvent, one equivalent of phosphorus oxychloride is added, and the amide compound is prepared. The reaction substrates are low in price and easy to get, the nature is stable, toxicity is small, the reaction speed is high, conditions are moderate, and the reaction substrates can be widely applied to substrates with different functional groups. The efficiently-constructed amide compound is an important molecular skeleton for many medicines, bioactive molecules and natural products, and the synthesizing method is a widely-applicable preparing method for synthesizing the compound.