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BOC-GLU(OTBU)-ONP, also known as tert-butyloxycarbonyl-L-glutamic acid (tert-butyl ester) p-nitrophenyl ester, is a chemical compound derived from L-glutamic acid, a naturally occurring amino acid in the human body. This derivative is characterized by its p-nitrophenyl ester moiety, which makes it a valuable substrate for enzymatic and chemical hydrolysis studies. It is widely utilized as a reagent in peptide synthesis and serves as a protecting group for the carboxyl group of amino acids, playing a crucial role in biochemical and pharmaceutical research.

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  • L-Glutamic acid,N-[(1,1-dimethylethoxy)carbonyl]-, 5-(1,1-dimethylethyl) 1-(4-nitrophenyl)ester

    Cas No: 69876-58-0

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  • 69876-58-0 Structure
  • Basic information

    1. Product Name: BOC-GLU(OTBU)-ONP
    2. Synonyms: BOC-GLU(OBUT)-ONP;BOC-GLU(OTBU)-ONP;BOC-GLUTAMIC ACID(OTBU)-ONP;BOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER ALPHA-4-NITROPHENYL ESTER;BOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER P-NITROPHENYL ESTER;BOC-L-GLUTAMIC ACID GAMMA-T-BUTYL-ALPHA-4-NITROPHENYL ESTER;BOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ALPHA-P-NITROPHENYL-DIESTER;BOC-L-GLUTAMIC ACID Y-T-BUTYL A-P-NITROPHENYL-DIESTER
    3. CAS NO:69876-58-0
    4. Molecular Formula: C20H28N2O8
    5. Molecular Weight: 424.44
    6. EINECS: N/A
    7. Product Categories: Amino Acids;Glutamic acid [Glu, E];Boc-Amino Acids and Derivative
    8. Mol File: 69876-58-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 555 °C at 760 mmHg
    3. Flash Point: 289.4 °C
    4. Appearance: /
    5. Density: 1.201 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: -15°C
    8. Solubility: N/A
    9. CAS DataBase Reference: BOC-GLU(OTBU)-ONP(CAS DataBase Reference)
    10. NIST Chemistry Reference: BOC-GLU(OTBU)-ONP(69876-58-0)
    11. EPA Substance Registry System: BOC-GLU(OTBU)-ONP(69876-58-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 69876-58-0(Hazardous Substances Data)

69876-58-0 Usage

Uses

Used in Peptide Synthesis:
BOC-GLU(OTBU)-ONP is used as a reagent in peptide synthesis for its ability to protect the carboxyl group of amino acids during the formation of peptide bonds. This protection is essential to prevent unwanted side reactions and ensure the correct sequence and structure of the synthesized peptide.
Used in Biochemical Research:
In biochemical research, BOC-GLU(OTBU)-ONP is employed as a substrate for enzymatic and chemical hydrolysis studies. Its p-nitrophenyl ester moiety allows for the monitoring of hydrolysis reactions, providing insights into enzyme specificity, kinetics, and mechanisms.
Used in Pharmaceutical Research:
BOC-GLU(OTBU)-ONP is utilized in pharmaceutical research for the development of new drugs and therapeutic agents. Its role as a protecting group for the carboxyl group of amino acids is crucial in the synthesis of peptide-based drugs, ensuring the correct structure and function of the final product.
Used in the Development of Drug Delivery Systems:
BOC-GLU(OTBU)-ONP can be used in the development of drug delivery systems, particularly for peptide-based drugs. Its ability to protect the carboxyl group of amino acids can help improve the stability and bioavailability of these drugs, enhancing their therapeutic efficacy.
Used in the Study of Enzyme Specificity and Kinetics:
BOC-GLU(OTBU)-ONP is used as a substrate in the study of enzyme specificity and kinetics, providing valuable information on the interactions between enzymes and their substrates. This knowledge can be applied to the design of more effective drugs and the understanding of enzymatic processes in various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 69876-58-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,8,7 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 69876-58:
(7*6)+(6*9)+(5*8)+(4*7)+(3*6)+(2*5)+(1*8)=200
200 % 10 = 0
So 69876-58-0 is a valid CAS Registry Number.

69876-58-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name BOC-GLU(OTBU)-ONP

1.2 Other means of identification

Product number -
Other names BOC-L-GLUTAMIC ACID Y-T-BUTYL A-P-NITROPHENYL-DIESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:69876-58-0 SDS

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