70258-18-3Relevant articles and documents
Use of silicon compounds in cyclization reaction
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Paragraph 0054; 0099-0120, (2021/06/23)
The invention relates to the field of organic chemistry, and in particular, relates to an application of silicon compounds in cyclization reaction. On one hand, the invention provides a preparation method of 2-chloro-5-chloromethylpyridine, and the preparation method comprises the steps: carrying out cyclization reaction on 4-formyl-4,5-dichlorovaleronitrile in the presence of a silicon compound and an amide compound to provide the 2-chloro-5-chloromethylpyridine. On the other hand, the invention provides a preparation method of 5-chloromethyl-2-trifluoromethyl-1,3,4-oxadiazole, and the preparation method comprises the steps: carrying out cyclization reaction on 1-(chloracetyl)-2-(trifluoroacetyl)hydrazine in the presence of a silicon compound and an amide compound to provide the 5-chloromethyl-2-trifluoromethyl-1,3,4-oxadiazole. By using the silicon compound or/and amide provided by the invention as a cyclization reagent, cyclization synthesis can be efficiently carried out.
Method for preparing chloromethylpyridine 2- chloride -5. (by machine translation)
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Paragraph 0034; 0040-0186, (2019/12/29)
The mass percentage of, the precious metal in 2 - the precious metal catalyst of the noble metal 2 - catalyst of the " invention is that the mass percentage of 1%-10%; the noble 2 - metal 2 - in the precious metal; catalyst, 2 - containing the active, carbon or, aluminum oxide as the carrier is, the mass percent of the noble metal catalyst in the precious metal catalyst with the active carbon or alumina as the carrier 0.1%-0.5%; 2 - 2 - 82%, 98%, ". (by machine translation)
Method for continuously preparing 2-chloro-5-chloromethylpyridine by microchannel reactor
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Paragraph 0017-0026, (2019/04/17)
The invention discloses a method for continuously preparing 2-chloro-5-chloromethylpyridine by a microchannel reactor. The method includes the following steps: simultaneously injecting 2-chloro-5-methylpyridine and chlorine as raw materials into the microchannel reactor for chlorination, collecting a reaction product after the reaction, and crystallizing and distilling the reaction product to obtain the 2-chloro-5-chloromethylpyridine. The method has the advantages that the microchannel reactor is applied to carry out the reaction, the mixing uniformity is high, and the reaction time is greatly shortened; the inner diameter of a microchannel is small while the specific surface area thereof is large, reaction materials are instantaneously mixed uniformly in a precise ratio, the raw materialutilization rate and the product quality are improved, and the selectivity of the product is high, so that the productivity and purity of the product are improved while the production cost is lowered; in addition, the use of organic solvents is avoided in the preparation process, no waste polluting the environment is discharged in the production process, and environmental pollution and harm to the human body are reduced.