70445-33-9 Usage
Description
Ethylhexylglycerin is also named as 3-(2-Ethylhexoxy)propane-1,2-diol or octoxyglycerin. It is a glyceryl ether. It is used as a weak preservative, as skin conditioning agent with effective wetting ability. It is used with phenoxyethanol in cosmetics to obtain better protection against microbial growth.
Chemical Properties
Ethylhexylglycerin is a glycerol monoalkylether of defined structure and high purity,with a 2-ethylhexyl group bound to the primary hydroxyl function of the glycerol molecule. Due to the fact that it is a crystal-clear,colourless liquid with a slightly characteristic odour it is well suited for the use in cosmetic products. Although it is less soluble in water(<0.1% at 25℃),it is more easily soluble in most common cosmetic alcohols and glycols as well as oils.Ethylhexylglycerin is rather stable, e.g. against hydrolysis and elevated temperatures and compatible with cosmetic ingredients. Ethylhexylglycerin is globally approved and as a new substance accords with the European legislation listed on the ELINCS file. International ApprovalsEurope / USA: INCl name: EthylhexylglycerinAustralia: AICS/NICNAS(NA/966),TGACanada:DSLJapan: ENCS as glycerin monoalkyl(or alkenyl,C8-C24)ether(No.: 2-414) CLS 199
Uses
Different sources of media describe the Uses of 70445-33-9 differently. You can refer to the following data:
1. Ethylhexylglycerin is a natural preservative, used as an alternative to parabens products. It is derived from natural glycerin. Also used as a deodorizer and skin conditioner.
Ethylhexylglycerin is a glyceryl ether and serves as an emollient solvent and a fixative with antimicrobial properties, and it is reported to enhance uptake of preservatives in microorganisms. It is often used as an alternative to parabens. The International Nomenclature of Cosmetic Ingredients name is Ethylhexylglycerin, and the chemical formula and synonym names are shown in Figure 1. Ethylhexylglycerin is a colorless to pale viscous liquid. It is reported to be used at a concentration up to 2% in leave-on products and 8% in rinse-off products. It is manufactured and marketed by Schu¨lke & Mayr GMBH, Norderstedt, Germany, under the trade name, Sensiva SC50, which is greater than 99% pure. Ethylhexylglycerin is found in many cosmetic products, that is, antiaging creams, sunscreens, eye shadows, eye creams, lip gloss, deodorants, facial moisturizers, and various types of cleansers.
2. Ethylhexylglycerin is the novel raw material for deodorants application and is widely used as a cosmetic emollient. Ethylhexylglycerin reliably inhibits the odor-causing bacteria, yeast and fungi on the skin.
Safety
With an EWG score of 1 and a rating of GOOD from Paula’s Choice, ethylhexylgylcerin is deemed to be very safe and a non-irritant.Ethylhexylglycerin is a topical skin care ingredient and deodorizing agent, often indicated as a conditioning ointment in the treatment of eczema. It can also be a surfactant and preservative-enhancer and can be found as a substituent for parabens. Ethylhexylglycerin is commonly found in baby products or cosmetics marketed as “hypoallergenic” or “formaldehyde free”.Ethylhexylglycerin has been reported to cause dermatitis and skin irritation.www.cir-safety.orgWhat Is Ethylhexylglcerin & Is It Safe?
Toxicity evaluation
The oral toxicity of ethylhexylglycerin (Sensiva? SC 50, in polyethylene glycol 400) at doses of 100, 500, and 1,500 mg/kg was evaluated in a 28-day study using groups of 10 rats of an unspecified strain. The test substance was administered at a dose volume of 5 ml/kg.There were no treatment-related mortalities. Body weight development was retarded in mid- and high-dose groups, and this finding was accompanied by a non-statistically significant reduction in food intake when compared to the control (polyethylene glycol 400) group. Both eye and ear functions remained unchanged during the study, and increased salivation (dose not stated) was the only clinical symptom observed. Hematological parameters were unaffected by treatment; however, serum analyses indicated changes in aminotransferase (above normal) in high-dose rats. Urinalysis and necropsy findings were unremarkable.
Reference
W. Beilfuss, M. Leschke, K. Weber, A New Concept to Boost the Preservative Efficacy of Phenoxyethanol, S?FW-Journal, 2005, vol. 131
Contact allergens
This glycerol monoalkylether is used as a skin conditioning
agent, with bactericidal properties against
Gram-positive bacteria.
Synthesis
Synthesis of ethylhexylglycerin?is via the catalytic splitting of ethylhexylglycidyl ether followed by the addition of water. The product can then be purified by vacuum distillation.
Check Digit Verification of cas no
The CAS Registry Mumber 70445-33-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,4,4 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 70445-33:
(7*7)+(6*0)+(5*4)+(4*4)+(3*5)+(2*3)+(1*3)=109
109 % 10 = 9
So 70445-33-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H24O3/c1-3-5-6-10(4-2)8-14-9-11(13)7-12/h10-13H,3-9H2,1-2H3
70445-33-9Relevant articles and documents
Method for continuously synthesizing ethylhexylglycerin by micro-channel reactor
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Paragraph 0026-0033, (2021/04/17)
The invention discloses a method for continuously synthesizing ethylhexylglycerin by using a micro-channel reactor. The method comprises the following steps: by using isooctyl alcohol, 3-chloro-1, 2-propylene glycol and inorganic base as raw materials, carrying out ethylhexylglycerin continuous synthesis by using the micro-channel reactor, separating the organic phase from a product, distilling and the like to obtain the high-purity ethylhexylglycerin product. According to the process method disclosed by the invention, the characteristics that the micro-channel reactor strengthens heat transfer and mass transfer and can realize accurate control are fully utilized; the defects of more byproducts, difficulty in control, poorer reaction selectivity, low product yield, complicated process, higher cost and the like caused by non-uniform reaction heating when the ethylhexylglycerin is synthesized by the conventional reactor equipment are overcome, continuous production and automatic control of the process can be realized, production is efficient and safe in production, mild reaction conditions, short reaction time, high product purity and yield are also realized, and the method is green and economic, and is beneficial to popularization and application of ethylhexylglycerin in cosmetics and daily chemical industries.
METHODS FOR PREPARING ALKYLGLYCERYL ETHERS
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Paragraph 0077; 0080; 0082; 0084; 0086-0089; 0091; 0092, (2018/08/07)
The present invention relates to a method for manufacturing alkyl glyceryl ether by conducting reaction of alkyl glycidyl ether and water in the presence of a solvent and a catalyst to obtain alkyl glyceryl ether, wherein the solvent comprises glycol ethers, and the catalyst comprises an alkali metal salt of a carboxylic acid. The method of the present invention does not require use of chemicals other than the solvent and the catalyst, so that the production cost is low and cost-effective.COPYRIGHT KIPO 2018
A process for preparing high purity ethyl hexyl glycerin method
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Paragraph 0031-0032, (2017/08/23)
The invention provides a method for preparing high-purity ethylhexylglycerin. According to the method, an intermediate 4-alkoxymethyl-1,3-dioxoane is generated from 2-ethylhexylglycidyl ether and acetone under the action of boron trifluoride diethyl etherate, a terminator is added in good time before hydrolysis, and after liquid separation, an oil-phase substance is neutralized by use of sodium hydrogen carbonate and then washed, next, a stabilizer is added, and finally, the high-purity ethylhexylglycerin is obtained by use of short-path distillation. The method is suitable for cosmetic additives and suitable for large-scale industrial production, and has the advantages of simple process, small energy consumption, product yield of greater than 88%, purity of 99.3%, no color and no taste, and the like.