70541-97-8

Basic information

• Product Name: 5-CYANO-3,4-DIMETHYLTHIOPHENE-2-CARBOXAMIDE
• Synonyms: 5-CYANO-3,4-DIMETHYLTHIOPHENE-2-CARBOXAMIDE
• CAS NO: 70541-97-8
• Molecular Formula: C8H8N2OS
• Molecular Weight: 180.22692
• Mol File: 70541-97-8.mol

Chemical Properties

• Melting Point: 192 °C(Solv: acetic acid (64-19-7))
• Boiling Point: 289.3±40.0 °C(Predicted)
• Appearance: /
• Density: 1.29±0.1 g/cm3(Predicted)
• PKA: 15.14±0.50(Predicted)
• CAS DataBase Reference: 5-CYANO-3,4-DIMETHYLTHIOPHENE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CYANO-3,4-DIMETHYLTHIOPHENE-2-CARBOXAMIDE(70541-97-8)
• EPA Substance Registry System: 5-CYANO-3,4-DIMETHYLTHIOPHENE-2-CARBOXAMIDE(70541-97-8)

Safety Data

• Hazardous Substances Data: 70541-97-8(Hazardous Substances Data)

Upstream product

• 5848-75-9 2-[(cyanomethyl)thio]acetonitrile 
• 431-03-8 dimethylglyoxal 

Downstream Products

• 155632-41-0 2,5-Dicyano-3,4-dimethylthiophene 

Relevant articles and documents

Synthesis and characterization of thiophene-derived amido bis-nitrogen mustard and its antimicrobial and anticancer activities

The thiophene-derived amido bis-nitrogen mustard N2,N 2,N5,N5-tetrakis(2-chloroethyl)-3,4- dimethylthiophene-2,5-dicarboxamide was designed and synthesized via five-step reactions from commercially available 2-chloroacetonitrile. This target compound was confirmed by 1H NMR, 13C NMR, MS, IR spectra and elemental analyses, and its structure was further characterized by X-ray single-crystal analysis. The biological activities for the title compound and some intermediates were evaluated in vitro for their antibacterial, antifungal and cytotoxic activities. The preliminary results showed that the title compound could inhibit efficiently the growth of the tested microorganisms including drug-resistant bacteria MRSA to some extent. Moreover, the target compound was found to be effective against prostatic carcinoma cell line (PC-3), breast carcinoma cell line (MCF-7), colon carcinoma (LoVo) and lung cancer (A549). Especially, it gave selective antitumor efficacy against prostatic carcinoma cell line (PC-3) at a low dose.

Synthesis and biological evaluation of novel benzimidazole derivatives and their binding behavior with bovine serum albumin

A series of novel benzimidazole derivatives were synthesized and characterized by 1H NMR, 13C NMR, MS, IR and HRMS spectra. All the new compounds were screened for their antimicrobial activities in vitro by two-fold serial dilution t

Synthesis of the First Thienothiophene Stabilized Only by Electronic Effects

The stable, crystalline 1,3-dibromo-4,6-dicyanothienothiophene (3a) has been synthesized.This is the first example of a thienothiophene stabilized solely by electronic effects.The dicarbomethoxy dibromo analog 3b and the tetrabromo analog 3c were also generated and found to be considerably less stable.