70892-82-9

Basic information

• Product Name: N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE
• Synonyms: N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE;LABOTEST-BB LT00453185;n,n-bis(2-hydroxyethyl)-4-pyridinecarboxamid;4-[[Bis(2-hydroxyethyl)amino]carbonyl]pyridine;N,N-Bis(2-hydroxyethyl)-4-pyridinecarboxamide;N,N-Bis(2-hydroxyethyl)pyridine-4-carboxamide
• CAS NO: 70892-82-9
• Molecular Formula: C₁₀H₁₄N₂O₃
• Molecular Weight: 210.23
• EINECS: 274-993-6
• Mol File: 70892-82-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 132-134 °C(lit.)
• Boiling Point: 456.6 °C at 760 mmHg
• Flash Point: 230 °C
• Appearance: /
• Density: 1.266
• Vapor Pressure: 3.94E-09mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE(70892-82-9)
• EPA Substance Registry System: N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE(70892-82-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 70892-82-9(Hazardous Substances Data)

Usage

General Description

N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE, also known as BI-2, is a chemical compound with a molecular formula C15H20N2O4. It is a diol derivative of isonicotinamide and has two hydroxyethyl groups attached to the nitrogen atom of the isonicotinamide ring. N,N-BIS(2-HYDROXYETHYL)ISONICOTINAMIDE is widely used in the pharmaceutical industry as a chelating agent and a ligand for metal ions, particularly for the complexation of transition metal ions. It is known for its ability to form stable complexes with metal ions, which makes it useful in various biochemical and medicinal applications. Additionally, it has been studied for its potential role in the treatment of metal ion-related diseases and as a part of drug delivery systems.

InChI:InChI=1/C10H14N2O3/c13-7-5-12(6-8-14)10(15)9-1-3-11-4-2-9/h1-4,13-14H,5-8H2

Upstream product

• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 111-42-2 2,2'-iminobis[ethanol] 

Relevant articles and documents

Silver-coordination polymer network combining antibacterial action and shape memory capabilities

In this study, a multifunctional polymer network is achieved by first synthesizing an isonicotinate-functionalized polyester (PIE) via classical melt-condensation polymerization, and secondly, the pendant of the pyrazinamide groups on the polyester side chains is coordinated with Ag ions to form a physically cross-linked network. Thermo property analysis and dynamic mechanical analysis reveal that the Ag-coordination polymer network possesses an excellent thermo-induced shape memory function, both under air and physiological conditions, due to a wide glass transition temperature region. The Ag ion concentration coordinated with the polymer was optimized to achieve the best shape memory effect using atomic absorption spectrometry. Moreover, the coordinated polyester can act as a reservoir of bactericidal Ag ions, in which the Ag ions are released and measured with inductively coupled plasma mass spectrometry, and in turn the antibacterial function is realized. Finally, the result of an Alamar blue assay reveals that the Ag-coordinated polyester has good cytocompatibility despite the introduction of a certain amount of Ag ions. Therefore, the multifunctional polymer has great potential applications in the biomedical field, e.g., burn wound dressings. the Partner Organisations 2014.