709-46-6Relevant articles and documents
Rational Design of Specific Recognition Molecules for Simultaneously Monitoring of Endogenous Polysulfide and Hydrogen Sulfide in the Mouse Brain
Dong, Hui,Zhou, Qi,Zhang, Limin,Tian, Yang
, p. 13948 - 13953 (2019)
A biosensor was created for the simultaneous monitoring of endogenous H2Sn and H2S in mouse brains and exploring their roles in activation of the TRPA1 channel under two types of brain disease models: ischemia and Alzheimer's disease (AD). Based on DFT calculations and electrochemical measurements, two probes, 3,4-bis((2-fluoro-5-nitrobenzoyl)oxy)-benzoic acid (MPS-1) and N-(4-(2,5-dinitrophenoxy) phenyl)-5-(1, 2-dithiolan-3-yl)pentanamide (MHS-1), were synthesized for specific recognition of H2Sn and H2S. Through co-assembly of the two probes at the mesoporous gold film with good anti-biofouling ability and electrocatalytic activity, this microsensor showed high selectivity for H2Sn and H2S against potential biological interferences. The biosensor can simultaneously determine the concentration of H2Sn from 0.2 to 50 μm, as well as that of H2S from 0.2 to 40 μm. The expression of TRPA1 protein positively correlated with levels of H2Sn under both ischemia and AD.
A single fluorescent probe for one- and two-photon imaging hydrogen sulfide and hydrogen polysulfides with different fluorescence signals
Zhao, Xinxin,He, Fangru,Dai, Yanpeng,Ma, Fulong,Qi, Zhengjian
, (2020)
Reactive sulfur species (RSS), primarily containing glutathione (GSH), cysteine (Cys), hydrogen sulfide (H2S) and hydrogen polysulfides (H2Sn, n > 1), were crucial endogenous biological signal molecules. Among them, H
Oxidative induction of β-turn conformations in cyclic peptidomimetics: Conformational analyses as indicators of configuration
Jiang, Luyong,Burgess, Kevin
, p. 9028 - 9029 (2002)
Solid-phase syntheses of the cyclic peptidomimetics 1-4 were performed. Sulfide 1 and sulfoxide 3 did not tend to exist in β-turn conformations in solution, but the sulfone 2 and the epimeric sulfoxide 4 did. The assignment of configuration of the sulfoxi
A highly selective fluorescent probe for hydrogen polysulfides in living cells based on a naphthalene derivative
Wang, Chunyan,Xu, Junhong,Ma, Qiujuan,Bai, Yu,Tian, Meiju,Sun, Jingguo,Zhang, Zhijuan
, (2020)
Hydrogen polysulfides (H2Sn, n > 1) are members of reactive sulfur species (RSS) and signaling molecules derived from hydrogen sulfide (H2S). Recently, the functions of H2Sn in physiological and patho
A Dinuclear Persulfide-Bridged Ruthenium Compound is a Hypoxia-Selective Hydrogen Sulfide (H2S) Donor
Woods, Joshua J.,Wilson, Justin J.
supporting information, p. 1588 - 1592 (2020/11/30)
Hydrogen sulfide (H2S) is a gaseous molecule that has received attention for its role in biological processes and therapeutic potential in diseases, such as ischemic reperfusion injury. Despite its clinical relevance, delivery of H2S to biological systems is hampered by its toxicity at high concentrations. Herein, we report the first metal-based H2S donor that delivers this gas selectively to hypoxic cells. We further show that H2S release from this compound protects H9c2 rat cardiomyoblasts from an in vitro model of ischemic reperfusion injury. These results validate the utility of redox-activated metal complexes as hypoxia-selective H2S-releasing agents for use as tools to study the role of this gaseous molecule in complex biological systems.