710-24-7Relevant articles and documents
Sulfination of acetanilide using liquid coordination complexes as dual catalyst and solvent
Shen, Jinghua,Wang, Fumin,Wang, Tianlei,Li, Haichao,Wang, Gang,Zhang, Xubin
, p. 56 - 60 (2019)
The Freidel-Crafts sulfination reaction of acetanilide with sulfur dioxide was catalyzed by several AlCl3-based liquid coordination complexes (LCCs), and the results were compared with that catalyzed by traditional ILs. Influences of different catalysts, ligand/AlCl3 molar ratios, and reaction conditions on their catalytic performance were investigated. The optimal result was obtained using acetamide-AlCl3-based LCC (molar ratio of acetamide to AlCl3 was 0.65, marked as 0.65 A A/AlCl3) as the catalyst, giving nearly 100% conversion of acetanilide within 60 min and 94.07% of selectivity to 4-acetamidobenzenesulfinic acid. AA/AlBr3 was synthesized and also showed catalytic activity for the sulfination reaction. Then a plausible reaction mechanism was proposed by investigation through the raman spectra.
Method for synthesizing aryl sulfonic acid by utilizing sulfur dioxide
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Paragraph 0036-0041; 0060-0065, (2018/01/04)
The invention relates to a method for synthesizing aryl sulfonic acid by utilizing sulfur dioxide. The method is characterized by comprising the following steps that S1, aromatic hydrocarbon is added into a solvent, stirring is performed to achieve complete dissolution, and then a catalyst is added; S2, under the stirring condition and the conditions of 0-100 DEG C and 0-10 atm, dried excessive sulfur dioxide gas or sulfur dioxide liquid are added, and reaction is performed for 0.5-50 hours; S3, the reaction liquid obtained in the step S2 is cooled to 10 DEG C or below, pressurized filtration is performed, and a catalyst is recovered; S4, filtrate is distilled to recover unreacted sulfur dioxide, then the solvent is recovered through distillation, the residual solid is the product aryl sulfonic acid, and the product yield is higher than 85%. The raw materials for the method for synthesizing the aryl sulfonic acid by utilizing the sulfur dioxide are cheap and easy to obtain, the product yield is high, the production process is safer, ad the severe environmental pollution of a traditional process is greatly reduced.
Substituted benzene derivatives useful as neuraminidase inhibitors
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, (2008/06/13)
A compound of the Formula (I): STR1 or pharmaceutically-suitable salts or prodrug forms thereof, wherein: n is 0-1; m is 0; p is 0-1; R1 is --CO2 H; R2 is selected from the group consisting of H, --OH, and --NH2 ; R3 is H; R4 is --C(O)NHR8 ; R5 is --NHC(R6)NH2 R6 is selected from the group consisting of =NH, =NOH, =NCN, =O, and =S; and R8 is selected from the group consisting of C1 -C4 linear or branched alkyl substituted with 0-3 halogens on each carbon.