710959-93-6Relevant articles and documents
Anti-MRSA agent discovery using diversity-oriented synthesis
Thomas, Gemma L.,Spandl, Richard J.,Glansdorp, Freija G.,Welch, Martin,Bender, Andreas,Cockfield, Joshua,Lindsay, Jodi A.,Bryant, Clare,Brown, Derek F. J.,Loiseleur, Olivier,Rudyk, Helene,Ladlow, Mark,Spring, David R.
supporting information; experimental part, p. 2808 - 2812 (2009/02/06)
Beating the superbugs: Diversity-oriented synthesis using a solid-supported phosphonate unit to synthesize 242 drug-like compounds based on 18 natural-productlike scaffolds led to the discovery of gemmacin (see scheme). This new structural class of antibiotic is active towards methicillin-resistant Staphylococcus aureus (MRSA). (Chemical Equation Presented).