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71294-03-6

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71294-03-6 Usage

General Description

7-Fluorooxindole is a chemical compound that belongs to the oxindole group, which is a class of heterocyclic aromatic organic compounds. It is characterized by the presence of a fluorine atom in the 7th position of the oxindole structure. This fluorinated oxindole derivative has shown potential applications in medicinal chemistry, particularly in the development of pharmaceuticals and agrochemicals. It has been investigated for its potential biological activity, including its role as a building block for the synthesis of biologically active molecules and as a precursor for the development of novel drug candidates. The introduction of the fluorine atom in the oxindole structure has been shown to influence the compound's physicochemical and biological properties, making it a valuable building block in drug discovery. Overall, 7-Fluorooxindole is a compound of interest in medicinal chemistry and may hold promise for future pharmaceutical developments.

Check Digit Verification of cas no

The CAS Registry Mumber 71294-03-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,2,9 and 4 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 71294-03:
(7*7)+(6*1)+(5*2)+(4*9)+(3*4)+(2*0)+(1*3)=116
116 % 10 = 6
So 71294-03-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H5F2NO/c9-5-1-4-2-8(12)11-7(4)3-6(5)10/h1,3H,2H2,(H,11,12)

71294-03-6 Well-known Company Product Price

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  • Alfa Aesar

  • (H61511)  7-Fluorooxindole, 95%   

  • 71294-03-6

  • 250mg

  • 303.0CNY

  • Detail
  • Alfa Aesar

  • (H61511)  7-Fluorooxindole, 95%   

  • 71294-03-6

  • 1g

  • 909.0CNY

  • Detail
  • Alfa Aesar

  • (H61511)  7-Fluorooxindole, 95%   

  • 71294-03-6

  • 5g

  • 3632.0CNY

  • Detail

71294-03-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-Fluorooxindole

1.2 Other means of identification

Product number -
Other names 7-fluoro-1,3-dihydroindol-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:71294-03-6 SDS

71294-03-6Relevant articles and documents

A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids

Liu, Li,Li, Yue,Huang, Tiao,Kong, Dulin,Wu, Mingshu

, p. 2321 - 2328 (2021/09/22)

A novel method for the synthesis of 3-monohalooxindoles by acidolysis of isatin-derived 3-phosphate-substituted oxindoles with haloid acids was developed. This synthetic strategy involved the preparation of 3-phosphate-substituted oxindole intermediates and SN1 reactions with haloid acids. This new procedure features mild reaction conditions, simple operation, good yield, readily available and inexpensive starting materials, and gram-scalability.

A safe and selective method for reduction of 2-nitrophenylacetic acid systems to N-aryl hydroxamic acids using continuous flow hydrogenation

Ichire, Ogar,Jans, Petra,Parfenov, Galina,Dounay, Amy B.

, p. 582 - 585 (2017/01/16)

The cyclic hydroxamic acid functional group is critical to the biological activity of numerous natural products and drug candidates. Efficient, reliable, and green synthetic methods to produce cyclic hydroxamic acids are needed. Herein, flow hydrogenation has been explored as a novel approach toward achieving the selective partial reduction of 2-nitrophenylacetic acid to 1-hydroxyindolin-2-one. The bidentate ligand, 1,10-phenanthroline, has been identified as a unique inhibitor for modulating product selectivity in this Pt/C-catalyzed process. Under the newly optimized reaction conditions, the targeted hydroxamic acid is produced with high selectivity (49:1) over the lactam by-product. The scope of the reaction is demonstrated for a variety of 2-nitrophenylacetic acid derivatives.

Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure-based design and in vivo reduction of amyloid β-peptides

Rueeger, Heinrich,Lueoend, Rainer,Rogel, Olivier,Rondeau, Jean-Michel,M?bitz, Henrik,MacHauer, Rainer,Jacobson, Laura,Staufenbiel, Matthias,Desrayaud, Sandrine,Neumann, Ulf

supporting information; experimental part, p. 3364 - 3386 (2012/06/01)

Structure-based design of a series of cyclic hydroxyethylamine BACE1 inhibitors allowed the rational incorporation of prime- and nonprime-side fragments to a central core template without any amide functionality. The core scaffold selection and the structure-activity relationship development were supported by molecular modeling studies and by X-ray analysis of BACE1 complexes with various ligands to expedite the optimization of the series. The direct extension from P1-aryl- and heteroaryl moieties into the S3 binding pocket allowed the enhancement of potency and selectivity over cathepsin D. Restraining the design and synthesis of compounds to a physicochemical property space consistent with central nervous system drugs led to inhibitors with improved blood-brain barrier permeability. Guided by structure-based optimization, we were able to obtain highly potent compounds such as 60p with enzymatic and cellular IC50 values of 2 and 50 nM, respectively, and with >200-fold selectivity over cathepsin D. Pharmacodynamic studies in APP51/16 transgenic mice at oral doses of 180 μmol/kg demonstrated significant reduction of brain Aβ levels.

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