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7148-05-2

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7148-05-2 Usage

General Description

3-(4-Methyl-piperazin-1-yl)-propionic acid ethyl ester is a chemical compound with a purity of over 98%. It is an ethyl ester derivative of the propionic acid and contains a piperazine functional group. 3-(4-METHYL-PIPERAZIN-1-YL)-PROPIONIC ACID ETHYL ESTER >98% is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used in research and development, and in the creation of new chemical compounds. Its high purity level indicates that it is suitable for various scientific and industrial applications.

Check Digit Verification of cas no

The CAS Registry Mumber 7148-05-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,1,4 and 8 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 7148-05:
(6*7)+(5*1)+(4*4)+(3*8)+(2*0)+(1*5)=92
92 % 10 = 2
So 7148-05-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H20N2O2/c1-3-14-10(13)4-5-12-8-6-11(2)7-9-12/h3-9H2,1-2H3

7148-05-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 3-(4-methylpiperazin-1-yl)propanoate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:7148-05-2 SDS

7148-05-2Relevant articles and documents

Synthesis and catalytic activity of porous polymer containing ionic liquid structures

Li, Junqiao,Lu, Wei,Li, Weifeng,Liang, Xuezheng

, p. 840 - 846 (2016/12/07)

A novel porous polymer containing ionic liquid (IL) structures was synthesized via quternization and condensation of 4-vinylpyridine and p-xylylene dichloride. The ionic liquid structures were incorporated in the polymeric framework and for this reason bulky IL molecules can hardly block pores and neutralize active sites. The polymer shows a high BET surface area and easily accessible active sites. Catalytically the polymer is very active in Michael additions with averaged yields over 96.0% achieved after short reaction times. The high BET surface, remarkable activity, operational simplicity, wide applicability and improved stability are the key properties of the polymer.

N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

González-Mu?oz, Gema C.,Arce, Mariana P.,López, Beatriz,Pérez, Concepción,Romero, Alejandro,Barrio, Laura Del,Martín-De-Saavedra, María Dolores,Egea, Javier,León, Rafael,Villarroya, Mercedes,López, Manuela G.,García, Antonio G.,Conde, Santiago,Rodríguez-Franco, María Isabel

body text, p. 2224 - 2235 (2011/06/22)

We have previously reported the multifunctional profile of N-(3-chloro-10H-phenothiazin-10-yl)-3-(dimethylamino)propanamide (1) as an effective neuroprotectant and selective butyrylcholinesterase inhibitor. In this paper, we have developed a series of N-acylaminophenothiazines obtained from our compound library or newly synthesised. At micro- and sub-micromolar concentrations, these compounds selectively inhibited butyrylcholinesterase (BuChE), protected neurons against damage caused by both exogenous and mitochondrial free radicals, showed low toxicity, and could penetrate into the CNS. In addition, N-(3-chloro-10H-phenothiazin-10-yl)-2-(pyrrolidin-1-yl) acetamide (11) modulated the cytosolic calcium concentration and protected human neuroblastoma cells against several toxics, such as calcium overload induced by an l-type Ca2+-channel agonist, tau-hyperphosphorylation induced by okadaic acid and Aβ peptide.

Structure-activity relationship of trihexyphenidyl analogs with respect to the dopamine transporter in the on going search for a cocaine inhibitor

Dar,Thiruvazhi,Abraham,Kitayama,Kopajtic,Gamliel,Slusher,Carroll,Uhl

, p. 1013 - 1021 (2007/10/03)

A series of trihexyphenidyl (THP) analogs were used to search for a derivative that could serve as a cocaine inhibitor. A compound that blocks binding of the cocaine analog carboxyfluorotropane (CFT), allows dopamine uptake and exhibits low side effects could serve as a good candidate for that purpose. All analogs were tested for the extent to which they inhibit CFT binding, dopamine uptake and n-methyl scopolamine (NMS) binding. Several structure-function relationships emerged. Methylation/halogenation of THP's benzene ring enhanced the compound's ability to block CFT binding in comparison to its ability to block dopamine uptake (5a-e). Replacement of the cyclohexyl ring with a benzene ring tended to create compounds that had lower affinities to the dopamine transporter (7b compared to THP, 7d compared to 5h, 7c compared to 8c) and modification of THP's piperidine ring tended to enhance affinity to the dopamine transporter (5f-h, 8a, 8c). One analog (5f) that showed little muscarinic activity indicating that it would probably have few side effects was investigated for its effects as an in vivo cocaine inhibitor. However, it showed few antagonistic effects in vivo. Nevertheless, this work greatly elucidates the structure-function relationships required for potential cocaine inhibitors and so lays out promising directions for future research.

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