7149-03-3

Basic information

• Product Name: 4-AMINO-3-BROMO-BENZOIC ACID ETHYL ESTER
• Synonyms: 4-AMINO-3-BROMO-BENZOIC ACID ETHYL ESTER;ETHYL 4-AMINO-3-BROMOBENZOATE;BUTTPARK 41\01-29;Ethyl-3-broMo-4-aMino benzoate;NSC 51689
• CAS NO: 7149-03-3
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244.09
• Product Categories: pharmacetical;Acids & Esters;Anilines, Amides & Amines;Bromine Compounds
• Mol File: 7149-03-3.mol
• Article Data: 24

Chemical Properties

• Melting Point: 90-92 °C
• Boiling Point: 345.2°C at 760 mmHg
• Flash Point: 162.6°C
• Appearance: /
• Density: 1.503g/cm³
• Vapor Pressure: 6.24E-05mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C(protect from light)
• PKA: 0.44±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-3-BROMO-BENZOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-3-BROMO-BENZOIC ACID ETHYL ESTER(7149-03-3)
• EPA Substance Registry System: 4-AMINO-3-BROMO-BENZOIC ACID ETHYL ESTER(7149-03-3)

Safety Data

• Hazardous Substances Data: 7149-03-3(Hazardous Substances Data)

Usage

General Description

4-Amino-3-Bromo-Benzoic Acid Ethyl Ester is a specialized chemical compound that contains a bromine atom and an amino group. It's in the class of benzoic acids and derivatives whose structure is characterized by a benzoic acid core in which an ethyl ester group is bonded to one of the carbon atoms and a bromo group and an amino group attached to the other carbon atoms. 4-AMINO-3-BROMO-BENZOIC ACID ETHYL ESTER is often used in organic synthesis. However, detailed information about its physical and chemical properties such as boiling point, melting point, density, and molecular weight might not be readily available considering this is a relatively specific and potentially less-studied compound. Its potential uses and safety measures should be evaluated based on further scientific research and experimentation.

InChI:InChI=1/C9H10BrNO2/c1-2-13-9(12)6-3-4-8(11)7(10)5-6/h3-5H,2,11H2,1H3

Upstream product

• 64-17-5 ethanol 
• 74103-28-9 3-bromo-4-acetamidobenzoic acid 
• 94-09-7 p-aminoethylbenzoate 
• 59096-06-9 4-(Trimethylsilanyl-amino)-benzoic acid ethyl ester 
• 150-13-0 4-amino-benzoic acid 

Downstream Products

• 86400-57-9 3-bromo-4-nitrobenzoic acid ethyl ester 
• 260559-79-3 ethyl 3-bromo-4-(N-tert-butoxycarbonyl)aminobenzoate 
• 1344727-49-6 ethyl 4-amino-3-(3-(trifluoromethyl)benzyl)benzoate 
• 1399743-47-5 C₂₁H₁₆BrNO₂ 
• 1399743-49-7 C₁₈H₁₁BrN₂O₂ 
• 1609391-09-4 C₁₂H₁₅NO₂ 
• 1609391-48-1 N-(2-amino-5-(thiophen-2-yl)phenyl)-8-cyclopropyl-2-(piperazin-1-yl)quinoline-6-carboxamide 
• 1609391-10-7 C₁₂H₁₄BrNO₂ 
• 1609391-11-8 C₁₇H₂₁NO₄ 
• 1395060-38-4 ethyl 4-amino-3-vinylbenzoate 
• 362527-61-5 ethyl 3-bromo-4-cyanobenzoate 
• 437707-51-2 ethyl 4-amino-3-bromo-5-iodobenzoate 
• 160425-34-3 ethyl 3-bromo-4-trifluoroacetamidobenzoate 

Relevant articles and documents

Aryl halide and synthesis method and application thereof

The invention discloses a synthesis method of aryl halides (including aryl bromide shown as a formula (2) and aryl iodide shown as a formula (3)). All the systems are carried out in an air atmosphere,visible light is utilized to excite a substrate or a photosensitizer to catalyze the reaction; and in a reaction solvent, when aromatic hydrocarbon shown in the formula (1) and sodium bromide serve as raw materials, aryl bromide shown in the formula (2) is obtained through a reaction under the auxiliary action of an additive (protonic acid); or when aromatic hydrocarbon shown in the formula (1) and sodium iodide are used as raw materials, under the auxiliary action of an additive (protonic acid), aryl iodide shown in the formula (3) is obtained through reaction. The synthesis method has the advantages of cheap and accessible raw materials, simple reaction operation and mild reaction conditions. The method is compatible with the arylamine which is liable to be oxidized. The invention provides a new method for the synthesis of aryl halides, realizes the amplification of basic chemicals aryl halides including aryl bromide shown in the formula (2) and aryl iodide shown in the formula (3),and has wide application prospect and practical value.

INDOLE DERIVATIVE USED AS CRTH2 INHIBITOR

The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.

Green synthesis method of bromoaromatic amine and alpha-bromoaromatic ketone

The invention discloses a green synthesis method of bromoaromatic amine and alpha-bromoaromatic ketone. The synthesis method comprises: adopting hydrobromic acid as a brominating agent, adopting 2-methylpyridine nitrate as a catalyst, and adopting molecular oxygen as an oxidizing agent, brominating an aromatic compound with a structure shown in formula (1) or aromatic ketone with a structure shown in formula (2) or (3), and preparing corresponding bromoaromatic amine or alpha-bromoaromatic ketone. The synthesis method is wide in substrate application reaction, high in atom utilization rate, capable of avoiding the application of the transitional metal element and volatile organic solvent and has the characteristics of economical efficiency and environmental protection. (Shown in the description).