71612-25-4

Basic information

• Product Name: 9-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one
• Synonyms: 7H-Furo(3,2-g)(1)benzopyran-7-one, 9-((3,7-dimethyl-2,6-octadienyl)oxy)-
• CAS NO: 71612-25-4
• Molecular Formula: C₂₁H₂₂O₄
• Molecular Weight: 338.397
• Mol File: 71612-25-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 503.7°C at 760 mmHg
• Flash Point: 258.4°C
• Density: 1.153g/cm³
• Vapor Pressure: 2.85E-10mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 9-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one(71612-25-4)
• EPA Substance Registry System: 9-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-7H-furo[3,2-g]chromen-7-one(71612-25-4)

Safety Data

• Hazardous Substances Data: 71612-25-4(Hazardous Substances Data)

Upstream product

• 6138-90-5 trans-geranyl bromide 
• 2009-24-7 8-hydroxypsoralen 
• 298-81-7 9-methoxy-7H-furo[3,2-g][1]benzopyran-7-one 

Downstream Products

• 143390-87-8 6',7'-Epoxy-8-geranyloxypsoralen 
• 2009-24-7 8-hydroxypsoralen 
• 68123-30-8 Dihydro-8-hydroxypsoralen 

Relevant articles and documents

Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor

The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins inhibited BACE1 activity, but simple coumarins and pyranocoumarins did not affect. The most potent inhibitor was 5-geranyloxy-8-methoxypsoralen (31), which has an IC50 value of 9.9 μM. Other furanocoumarin derivatives, for example, 8-geranyloxy-5- methoxypsoralen (35), 8-geranyloxypsoralen (24), and bergamottin (18) inhibited BACE1 activity, with the IC50 values 25.0 μM. Analyses of the inhibition mechanism by Dixon plots and Cornish-Bowden plots showed that compounds 18, 31 and 35 were mixed-type inhibitor. The kinetics of inhibition of BACE1 by coumarins 24 was non-competitive inhibitors.