719-59-5Relevant articles and documents
Preparation method of 2-amino-5-chlorobenzophenone
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Paragraph 0025-0053, (2022/01/08)
The present invention proposes a method for preparing 2-amino-5-chlorobenzophenone, comprising: Step S1, the 5-chloro-3-phenyl-2,1-benzisoxazole is mixed with a catalyst, ethyl acetate is added, stirred until dissolved, the reaction system is maintained in a hydrogen atmosphere, the reaction pressure is controlled at 1-5atm, 20-30 ° C reaction; step S2, the reaction solution obtained in step S1 is filtered and the solvent is removed, the thick is obtained, a crystalline solvent is added to the thick, and after heating and dissolving, Cooling crystallization is filtered to give 2-amino-5-chlorobenzophenone. The preparation of the opposite of the present invention compared to the prior art, the yield of the product is higher, while there are fewer impurities, the reaction conditions are relatively mild, suitable for large-scale industrial applications.
One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors
Fan, Hui,Xu, Shijie,Yang, Fan,Zhang, Xiaoxiang,Zhao, Xuechun
supporting information, p. 4555 - 4558 (2021/08/30)
We describe a novel one-pot three-step reaction of 2-alkynyl arylazides through palladium-catalyzed formation of 3-hydroxy-3-phenylindolin-2-ones followed by hydrolysis of amide bonds and copper-catalyzed decarboxylation to give 2-aminobenzophenones. This synthetic method works well with various 2-alkynyl arylazides and affords the products in moderate to good yields under mild reaction conditions.
Xantphos-ligated palladium dithiolates: An unprecedented and convenient catalyst for the carbonylative Suzuki–Miyaura cross-coupling reaction with high turnover number and turnover frequency
Gaikwad, Vinayak V.,Mane, Pravin A.,Dey, Sandip,Bhanage, Bhalchandra M.
, (2019/11/19)
Xantphos- and dithiolate-ligated macrocyclic palladium complexes as an efficient and stable catalyst for the carbonylative Suzuki–Miyaura cross-coupling reaction have been synthesized. The catalysts were characterized by 1H-nuclear magnetic resonance (NMR), CHNS (carbon, hydrogen, nitrogen, and sulfur) analysis, melting point analysis, and 31P-NMR spectroscopy. Several sensitive functional groups (e.g., –NO2, –F, –Cl, –Br, –NH2, and –CN) on the aromatic ring were well tolerated in the carbonylative Suzuki–Miyaura coupling reaction. The present palladium complexes produce six times higher turnover number (TON) and five times higher turnover frequency (TOF) compared with conventional homogeneous palladium precursors. Maximum TONs in the range of 105 to 106 and TOF in the range of 104 to 105 could be generated by a very low amount of catalyst loading (10–5?mol%).