71972-47-9Relevant articles and documents
Rhodium-Catalyzed Asymmetric Transfer Hydrogenation/Dynamic Kinetic Resolution of 3-Benzylidene-Chromanones
Molina Betancourt, Ricardo,Phansavath, Phannarath,Ratovelomanana-Vidal, Virginie
supporting information, p. 1621 - 1625 (2021/03/08)
Straightforward access to enantiomerically enriched cis-3-benzyl-chromanols from (E)-3-benzylidene-chromanones was developed through Rh-catalyzed asymmetric transfer hydrogenation. This transformation allowed the reduction of both the CaC and CaO bonds and the formation of two stereocenters in high yields with excellent levels of diastereo- A nd enantioselectivities (up to >99:1 dr, up to >99% ee) in a single step through a dynamic kinetic resolution process using a low catalyst loading and HCO2H/DABCO as the hydrogen source.
Synthesis, structure, and estrogenic activity of 2- and 3-substituted 2,3-dihydro-4H-1-benzopyran-4-ones
Jacquot, Yves,Byrne, Cillian,Xicluna, Alain,Leclercq, Guy
, p. 681 - 691 (2013/04/10)
Molecules with potent estrogenic activity are ~270 A3 hydrophobic structures that encompass two hydroxyls among which is at least one phenol. However, compounds with only one phenol or devoid of such a ring have been shown to enhance ERα-mediat
Design, synthesis and antiproliferative activity of some 3-benzylidene-2,3-dihydro-1-benzopyran-4-ones which display selective toxicity for malignant cells
Perjesi, Pal,Das, Umashankar,De Clercq, Erik,Balzarini, Jan,Kawase, Masame,Sakagami, Hiroshi,Stables, James P.,Lorand, Tamas,Rozmer, Zsuzsanna,Dimmock, Jonathan R.
, p. 839 - 845 (2008/09/20)
A series of 3-benzylidene-4-chromanones 1a-l were prepared and their cytotoxicity towards human Molt 4/C8 and CEM T-lymphocytes as well as murine L1210 lymphoid leukemia cells were compared to the previously generated biodata in these three assays for the