721-65-3

Basic information

• Product Name: N-CHLOROACETYL-L-PHENYLALANINE
• Synonyms: CLAC-PHE-OH;CHLOROAC-PHE-OH;CHLOROACETYL-L-PHENYLALANINE;N-CHLOROACETYL-L-PHE;N-CHLOROACETYL-L-PHENYLALANINE;N-chloroacetyl-L-phenylalanine*crystalline;N-(2-Chloroacetyl)-B-phenyl-L-alanine;N-(2-Chloroacetyl)-L-phenylalanine
• CAS NO: 721-65-3
• Molecular Formula: C₁₁H₁₂ClNO₃
• Molecular Weight: 241.67
• Product Categories: A - H;Amino Acids;Modified Amino Acids
• Mol File: 721-65-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: N-CHLOROACETYL-L-PHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CHLOROACETYL-L-PHENYLALANINE(721-65-3)
• EPA Substance Registry System: N-CHLOROACETYL-L-PHENYLALANINE(721-65-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 721-65-3(Hazardous Substances Data)

Usage

General Description

N-Chloroacetyl-L-phenylalanine is a chemical compound that combines the amino acid phenylalanine with a chloroacetyl group. It is commonly used in the synthesis of peptides and proteins by introducing the N-chloroacetyl group to the amino acid side chains. This chemical plays a crucial role in the preparation of peptide-based drugs and pharmaceuticals due to its ability to facilitate peptide bond formation and modification. Additionally, N-Chloroacetyl-L-phenylalanine can also be used as a precursor in the development of various bioactive compounds and in the study of protein structure and function. It is important to handle this compound with care as it may pose health hazards and should only be used in a controlled laboratory setting.

Upstream product

• 63-91-2 L-phenylalanine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 76385-72-3 (S)-3-Phenyl-2-(2-phosphono-acetylamino)-propionic acid ethyl ester 
• 82283-70-3 C₁₁H₁₁NO₆P^(3-)*3Na⁽¹⁺⁾ 
• 904789-99-7 (S)-2-(2-azidoacetamido)-3-phenylpropanoic acid 
• 1381762-71-5 (S)-S-phenyl 2-(2-azidoacetamido)-3-phenylpropanethioate 
• 5037-75-2 cyclo(Gly-Phe) 
• 1474030-27-7 (S)-3-phenyl-2-[2-(phenylselenyl)acetamido]propanoic acid 
• 63-91-2 L-phenylalanine 
• 75189-51-4 glycylphenylalanylmethioninamide hydrochloride 
• 682334-42-5 2-[(3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carbonyl)-amino]-3-phenyl-propionic acid 
• 682334-30-1 (S)-2-[2-(3-Cyano-4,6-dimethyl-pyridin-2-ylsulfanyl)-acetylamino]-3-phenyl-propionic acid 
• 76385-62-1 (S)-ethyl 2-(2-(diethoxyphosphoryl)acetamido)-3-phenylpropanoate 
• 82283-65-6 (S)-2-[2-(Dimethoxy-phosphoryl)-acetylamino]-3-phenyl-propionic acid methyl ester 

Relevant articles and documents

One-pot synthesis of phenylseleno N-acetyl α-amino acids: Supra-molecular self-assembling in organoselenium compounds

A convenient one-pot synthesis of phenylseleno N-acetyl α-amino acids, PhSeCH2C(O)NHC(R)COOH (R = H (1), Me (2), PhCH2 (3), 4-HOC6H4CH2 (4) and CH2OH (5)) is reported. These compounds have been characterized by microanalyses, UV-Vis, IR and NMR (1H, 13C, 77Se) spectroscopy. The molecular structures of [PhSeCH2CONHCH2COOH] (1), [PhSeCH2CONHCH(CH2C6H4OH-4)COOH] (4) and [PhSeCH2CONHCH(CH2OH)COOH] (5) have been established by X-ray diffraction analyses. These compounds are associated in the solid state through hydrogen bonding to give supra-molecular self-assembled structures. Free radical scavenging activity of these compounds has also been evaluated by DPPH assay.