721926-88-1

Basic information

• Product Name: Methyl 6-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxyIate
• Synonyms: Methyl 6-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxyIate;METHYL 6-METHYL-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE-2-CARBOXYLATE
• CAS NO: 721926-88-1
• Molecular Formula: C10H13NO2S
• Molecular Weight: 211.28072
• Mol File: 721926-88-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 336.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.209±0.06 g/cm3(Predicted)
• PKA: 7.49±0.20(Predicted)
• CAS DataBase Reference: Methyl 6-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxyIate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 6-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxyIate(721926-88-1)
• EPA Substance Registry System: Methyl 6-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxyIate(721926-88-1)

Safety Data

• Hazardous Substances Data: 721926-88-1(Hazardous Substances Data)

Upstream product

• 870243-58-6 methyl thieno[2,3-c]pyridine-2-carboxylate 
• 74-88-4 methyl iodide 
• 40273-47-0 3-fluoropyridine-4-carbaldehyde 

Downstream Products

• 1259287-72-3 methyl 4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate 
• 1259287-87-0 C₁₄H₁₉NO₃S 
• 1259286-35-5 6-(cyclohexylcarbonyl)-N-hydroxy-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxamide 

Relevant articles and documents

Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N- hydroxybenzamide with high selectivity for the HDAC6 isoform

A screen for HDAC6 inhibitors identified acyl derivatives of 4-(aminomethyl)-N-hydroxybenzamide as potent leads with unexpected selectivity over the other subtypes. We designed and synthesized constrained heterocyclic analogues such as tetrahydroisoquinolines that show further enhanced HDAC6 selectivity and inhibitory activity in cellular assays. Selectivity may be attributed to the benzylic spacer more effectively accessing the wider channel of HDAC6 compared to other HDAC subtypes as well as hydrophobic capping groups interacting with the protein surface near the rim of the active site.