722-21-4

Basic information

• Product Name: (E)-4-(4-Methoxystyryl)pyridine
• Synonyms: (E)-4-(4-Methoxystyryl)pyridine
• CAS NO: 722-21-4
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.25912
• Mol File: 722-21-4.mol
• Article Data: 19

Chemical Properties

• Melting Point: 128 °C
• Boiling Point: 363.0±11.0 °C(Predicted)
• Appearance: /
• Density: 1.112±0.06 g/cm3(Predicted)
• PKA: 6.03±0.10(Predicted)
• CAS DataBase Reference: (E)-4-(4-Methoxystyryl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(4-Methoxystyryl)pyridine(722-21-4)
• EPA Substance Registry System: (E)-4-(4-Methoxystyryl)pyridine(722-21-4)

Safety Data

• Hazardous Substances Data: 722-21-4(Hazardous Substances Data)

Usage

General Description

(E)-4-(4-Methoxystyryl)pyridine is a organic chemical compound with a molecular formula C13H11NO. It is a derivative of pyridine and contains a styryl group as well as a methoxy group. (E)-4-(4-Methoxystyryl)pyridine is used in the field of organic synthesis and as a building block for various pharmaceuticals and agrochemicals. It is also used as a biological stain in cell imaging and research. Additionally, (E)-4-(4-Methoxystyryl)pyridine has been studied for its potential antioxidant and antimicrobial properties, making it a subject of interest for further research in medicinal chemistry.

Upstream product

• 108-89-4 picoline 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-43-6 4-vinylpyridine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 108-98-5 thiophenol 
• 637-69-4 4-Methoxystyrene 
• 1120-87-2 4-bromopyridin 
• 1620-52-6 4-((benzenesulfonyl)methyl)pyridine 
• 105-13-5 4-Methoxybenzyl alcohol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 3462-97-3 (4-methoxybenzyl)triphenylphosphonium bromide 
• 99-96-7 4-hydroxy-benzoic acid 
• 824-94-2 p-methoxybenzyl chloride 
• 121-98-2 methyl 4-methoxybenzoate 

Downstream Products

• 6043-46-5 cis-4'-methoxy-4-stilbazole 
• 1383439-22-2 C₁₄H₁₃NO*ClHO₄ 
• 654662-60-9 4-(2-[p-methoxyphenyl]ethyl)piperidine 
• 85717-48-2 cis-(Ru(bpy)2(4'-OMe-stilb)2)(PF₆)2 

Relevant articles and documents

A new insight into the push-pull effect of substituents via the stilbene-like model compounds

In this paper, authors report on 1-pyridyl-2-arylethenes, 1-furyl-2-arylethylenes, 1,2-diphenylpropylenes and substituted cinnamyl anilines as stilbene-like model compounds to investigate the factors dominating the push-pull effect of substituents via usi

Effect of N-substituent in 4-styrylpyridinium dyes on their binding to DNA

4-Styrylpyridinium dyes containing N-methyl and N-(3-pyridiniopropyl) substituents have been prepared and characterized by optical and CD spectroscopy. These compounds demonstrate affinity to calf thymus DNA, with dye–DNA binding mode being different for

1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2

A series of 1,4-diphenalkylpiperidine analogs were synthesized and evaluated for their affinity and inhibitory potency at the [3H]dihydrotetrabenazine (DTBZ) binding site and [3H]dopamine (DA) uptake site on the vesicular monoamine transporter-2 (VMAT2). Results revealed that translocation of the phenethyl side chains of lobelane from C2 and C6 to C1 and C4 around the central piperidine ring slightly reduces affinity and inhibitory potency at VMAT2 with respect to lobelane. However, methoxy and fluoro-substitution of either phenyl ring of these 1,4-diphenethyl analogs afforded VMAT2 inhibition comparable or higher (5-fold) affinity at the DTBZ binding and DA uptake sites relative to lobelane, whereas replacement of the 4-phenethyl moiety in these analogs with a 4-phenmethyl moiety markedly reduced affinity for the DTBZ binding and DA uptake sites by 3- and 5-fold, respectively. Among the twenty five 1,4-diphenethylpiperidine analogs evaluated, compounds containing a 4-(2-methoxyphenethyl) moiety exhibited the most potent inhibition of DTBZ binding and vesicular DA uptake. From this subgroup, analogs 8h, 8j and 8m exhibited Ki values of 9.3 nM, 13 nM and 13 nM, respectively, for inhibition of [3H]DA uptake by VMAT2, and represent some of the most potent inhibitors of VMAT2 function reported thus far.