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72204-21-8

Cbz-cis-4-fluoro-Pro-OH is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • N-Carbobenzoxy-cis-4-fluoro-L-proline;(2S,4R)-1-Carbobenzoxy-4-Fluoropyrrolidine-2-carboxylic acid

    Cas No: 72204-21-8

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  • 72204-21-8 Structure

  • Basic information

    1. Product Name: Cbz-cis-4-fluoro-Pro-OH
    2. Synonyms: Cbz-cis-4-fluoro-Pro-OH;(2S,4S)-1-((benzyloxy)carbonyl)-4-fluoropyrrolidine-2-carboxylic acid;(2S,4S)-1-((benzyloxy)carbonyl)-4-fluoropyrrolidine-2-carboxylic acid(WXFC0252)
    3. CAS NO:72204-21-8
    4. Molecular Formula: C13H14FNO4
    5. Molecular Weight: 267.2529632
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 72204-21-8.mol

  • Chemical Properties

    1. Melting Point: 123-124 °C
    2. Boiling Point: 440.9±45.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.35±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 3.52±0.40(Predicted)
    10. CAS DataBase Reference: Cbz-cis-4-fluoro-Pro-OH(CAS DataBase Reference)
    11. NIST Chemistry Reference: Cbz-cis-4-fluoro-Pro-OH(72204-21-8)
    12. EPA Substance Registry System: Cbz-cis-4-fluoro-Pro-OH(72204-21-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 72204-21-8(Hazardous Substances Data)

72204-21-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 72204-21-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,2,0 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 72204-21:
(7*7)+(6*2)+(5*2)+(4*0)+(3*4)+(2*2)+(1*1)=88
88 % 10 = 8
So 72204-21-8 is a valid CAS Registry Number.

72204-21-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-benzyloxycarbonyl-(4S)-fluoro-L-proline

1.2 Other means of identification

Product number -
Other names CBZ-CIS-4-FLUORO-L-PROLINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:72204-21-8 SDS

72204-21-8Relevant articles and documents

BENZIMIDAZOLE-LINKED INDOLE COMPOUND ACTING AS NOVEL DIVALENT IAP ANTAGONIST

-

Paragraph 0168; 0170, (2019/03/14)

The present invention discloses a benzimidazole-linked indole compound acting as novel divalent IAP antagonist, specifically disclosing the compound shown in fomulas (I) or a pharmaceutically acceptable salt thereof.

Discovery and synthesis of HIV integrase inhibitors: Development of potent and orally bioavailable N-methyl pyrimidones

Gardelli, Cristina,Nizi, Emanuela,Muraglia, Ester,Crescenzi, Benedetta,Ferrara, Marco,Orvieto, Federica,Pace, Paola,Pescatore, Giovanna,Poma, Marco,Ferreira, Maria Del Rosario Rico,Scarpelli, Rita,Homnick, Carl F.,Ikemoto, Norihiro,Alfieri, Anna,Verdirame, Maria,Bonelli, Fabio,Paz, Odalys Gonzalez,Taliani, Marina,Monteagudo, Edith,Pesci, Silvia,Laufer, Ralph,Felock, Peter,Stillmock, Kara A.,Hazuda, Daria,Rowley, Michael,Summa, Vincenzo

, p. 4953 - 4975 (2008/03/14)

The human immunodeficiency virus type-1 (HIV-1) encodes three enzymes essential for viral replication: a reverse transcriptase, a protease, and an integrase. The latter is responsible for the integration of the viral genome into the human genome and, therefore, represents an attractive target for chemotherapeutic intervention against AIDS. A drug based on this mechanism has not yet been approved. Benzyl-dihydroxypyrimidine-carboxamides were discovered in our laboratories as a novel and metabolically stable class of agents that exhibits potent inhibition of the HIV integrase strand transfer step. Further efforts led to very potent compounds based on the structurally related N-Me pyrimidone scaffold. One of the more interesting compounds in this series is the 2-N-Me-morpholino derivative 27a, which shows a CIC95 of 65 nM in the cell in the presence of serum. The compound has favorable pharmacokinetic properties in three preclinical species and shows no liabilities in several counterscreening assays.

Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors

Ganellin, C. Robin,Bishop, Paul B.,Bambal, Ramesh B.,Chan, Suzanne M. T.,Leblond, Bertrand,Moore, Andrew N. J.,Zhao, Lihua,Bourgeat, Pierre,Rose, Christiane,Vargas, Froylan,Schwartz, Jean-Charles

, p. 7333 - 7342 (2007/10/03)

The cholecystokinin-8 (CCK-8)-inactivating peptidase is a serine peptidase that has been shown to be a membrane-bound isoform of tripeptidyl peptidase II (EC 3.4.14.10). It cleaves the neurotransmitter CCK-8 sulfate at the Met-Gly bond to give Asp-Tyr(SO

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