7223-30-5

Basic information

• Product Name: 3-PHENYLPROP-2-YNAMIDE
• Synonyms: 3-PHENYLPROP-2-YNAMIDE;3-Phenylpropiolamide
• CAS NO: 7223-30-5
• Molecular Formula: C₉H₇NO
• Molecular Weight: 145.16
• Mol File: 7223-30-5.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 280.4±23.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.06±0.50(Predicted)
• CAS DataBase Reference: 3-PHENYLPROP-2-YNAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYLPROP-2-YNAMIDE(7223-30-5)
• EPA Substance Registry System: 3-PHENYLPROP-2-YNAMIDE(7223-30-5)

Safety Data

• Hazardous Substances Data: 7223-30-5(Hazardous Substances Data)

Upstream product

• 637-44-5 phenylpropyolic acid 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 7342-02-1 3-phenylpropynoic acid phenylamide 
• 536-74-3 phenylacetylene 
• 4891-38-7 phenylpropynoic acid methyl ester 
• 1336-21-6 ammonium hydroxide 
• 3019-71-4 Trichloroacetyl isocyanate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 2216-94-6 phenylpropynoic acid ethyl ester 
• 1817-57-8 4-phenyl-3-butyne-2-one 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 15783-70-7 5-amino-3-phenylisoxazole-4-carboxamide 

Downstream Products

• 3806-42-6 5-benzylidene-2-thioxothiazolidin-4-one 
• 3774-99-0 5-benzylidene-2,4-thiazolidinedione 
• 109346-01-2 3-Methyl-5-[1-phenyl-meth-(E)-ylidene]-2-[(E)-propylimino]-thiazolidin-4-one 
• 3446-58-0 3-oxo-3-phenylpropanamide 
• 881877-45-8 4-hydroxy-5-phenyl-2-(phenylethynyl)-6H-1,3-oxazin-6-one 
• 1392486-29-1 (Z)-2-(chloro(phenyl)methylene)pent-4-enamide 
• 7474-19-3 3,3-diphenylpropionamide 
• 132067-91-5 (Z)-3-(tert-Butylamino)-3-phenylprop-2-enoic acid amide 
• 106658-34-8 2-benzyl-4-phenyl-6-pyrimidone 
• 38771-64-1 5-benzylidene-2-phenylimino-thiazolidine-4-one 
• 36937-23-2 5-Benzyliden-3-n-propylimino-4-thiazolidinon 
• 935-02-4 3-Phenyl-2-propynonitrile 
• 3774-99-0 (Z)-5-benzylidene-1,3-thiazolidine-2,4-dione 
• 621-79-4 cinnamamide 

Relevant articles and documents

AlBr3-Promoted stereoselective anti-hydroarylation of the acetylene bond in 3-arylpropynenitriles by electron-rich arenes: Synthesis of 3,3-diarylpropenenitriles

Reactions of 3-arylpropynenitriles (ArC≡CCN) with electron-rich arenes (Ar'H, benzene and its polymethylated derivatives) under the action of aluminum bromide (AlBr3, 6 equiv) at room temperature for 0.5-2 h result in the stereoselective formation of 3,3-

Z-Selective phosphine promoted 1,4-reduction of ynoates and propynoic amides in the presence of water

Phosphine-mediated reductions of substituted propynoic esters and amides in the presence of water yield the partially reduced α,β-unsaturated esters and amides with highZ-selectivity. The competitivein situ ZtoE-isomerization of the product in some cases lowers theZtoEratios of the isolated α,β-unsaturated carbonyl products. Reaction time and the amounts of phosphine and water in the reaction mixture are the key experimental factors which control the selectivity by preventing or reducing the rates ofZ- toE-product isomerization. Close reaction monitoring enables isolation of theZ-alkenes with high selectivities. The computational results suggest that the reactions could be highlyZ-selective owing to the stereoselective formation of theE-P-hydroxyphosphorane intermediate.

Water as a Hydrogenating Agent: Stereodivergent Pd-Catalyzed Semihydrogenation of Alkynes

Palladium-catalyzed transfer semihydrogenation of alkynes using H2O as the hydrogen source and Mn as the reducing reagent is developed, affording cis- and trans-alkenes selectively under mild conditions. In addition, this method provides an efficient way to access various cis-1,2-dideuterioalkenes and trans-1,2-dideuterioalkenes by using D2O instead of H2O.