72496-41-4

Basic information

• Product Name: Pirarubicin
• Synonyms: THP-ADM;THEPRUBICIN;(8s-cis)-droxyacetyl)-1-methoxy;1609rb;4’-o-tetrahydropyranyladriamycin;4’-o-tetrahydropyranyldoxorubicin;5,12-naphthacenedione,10-((3-amino-2,3,6-trideoxy-4-o-(tetrahydro-2h-pyran-2-y;l)-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hy
• CAS NO: 72496-41-4
• Molecular Formula: C32H37NO12
• Molecular Weight: 627.64
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;API;Inhibitors
• Mol File: 72496-41-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 188-192°C (dec.)
• Boiling Point: 834.659 °C at 760 mmHg
• Flash Point: 458.586 °C
• Appearance: Red crystalline powder
• Density: 1.519 g/cm³
• Vapor Pressure: 1.51E-29mmHg at 25°C
• Refractive Index: 1.67
• Storage Temp.: 2-8°C
• Solubility: ethanol: soluble25mg/mL
• PKA: 7.35±0.60(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Pirarubicin(CAS DataBase Reference)
• NIST Chemistry Reference: Pirarubicin(72496-41-4)
• EPA Substance Registry System: Pirarubicin(72496-41-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: QI9296000
• Hazardous Substances Data: 72496-41-4(Hazardous Substances Data)

Usage

Description

Pirarubicin is a new anthracycline anticancer agent structurally related to doxorubicin. In acute leukemia, non-Hodgkin’s lymphoma, breast and ovariail carcinoma, pirarubicin is reportedly superior to doxorubicin and better tolerated. Its major side-effect appears to be myelosuppression, mainly in the form of leucopenia, which is potentially dose-limiting.

Chemical Properties

Red Solid

Uses

Different sources of media describe the Uses of 72496-41-4 differently. You can refer to the following data:
1. Structural analog of Doxorubicin. Antineoplastic.
2. Structural analog of Doxorubicin. Antineoplastic

Brand name

Pinorubicin; Therarubucin

InChI:InChI=1/C32H37NO12/c1-14-31(45-21-8-3-4-9-42-21)17(33)10-22(43-14)44-19-12-32(40,20(35)13-34)11-16-24(19)30(39)26-25(28(16)37)27(36)15-6-5-7-18(41-2)23(15)29(26)38/h5-7,14,17,19,21-22,31,34,37,39-40H,3-4,8-13,33H2,1-2H3/t14-,17-,19?,21+,22-,31+,32-/m0/s1

Relevant articles and documents

Tetrahydropyranyl derivatives of daunomycin and adriamycin

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